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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2hvn ZST Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2hvn ZSTAldose reductase 1.1.1.21 1.210
2fz8 ZSTAldose reductase 1.1.1.21 1.205
2hvo ZSTAldose reductase 1.1.1.21 1.167
2pdi ZSTAldose reductase 1.1.1.21 1.122
2duz ZSTAldose reductase 1.1.1.21 1.102
2hv5 ZSTAldose reductase 1.1.1.21 1.090
2fz9 ZSTAldose reductase 1.1.1.21 1.089
2pdb ZSTAldose reductase 1.1.1.21 1.089
2pdm ZSTAldose reductase 1.1.1.21 1.060
3len ZSTAldose reductase 1.1.1.21 1.057
2pd5 ZSTAldose reductase 1.1.1.21 1.048
3m0i ZSTAldose reductase 1.1.1.21 1.028
2dv0 ZSTAldose reductase 1.1.1.21 1.015
3mb9 ZSTAldose reductase 1.1.1.21 0.995
2pdx ZSTAldose reductase 1.1.1.21 0.901
2dux ZSTAldose reductase 1.1.1.21 0.884
2pdq 47DAldose reductase 1.1.1.21 0.881
4gca 2X9Aldose reductase 1.1.1.21 0.856
1z3n 3NAAldose reductase 1.1.1.21 0.829
2pdf ZSTAldose reductase 1.1.1.21 0.809
1frb ZSTAldose reductase-related protein 2 / 0.784
2pdg 47DAldose reductase 1.1.1.21 0.777
2pdp 393Aldose reductase 1.1.1.21 0.771
3g5e Q74Aldose reductase 1.1.1.21 0.763
1t40 ID5Aldose reductase 1.1.1.21 0.759
2pdj 393Aldose reductase 1.1.1.21 0.755
2pdu 393Aldose reductase 1.1.1.21 0.741
1us0 LDTAldose reductase 1.1.1.21 0.728
2pzn 393Aldose reductase 1.1.1.21 0.714
3m64 393Aldose reductase 1.1.1.21 0.714
3lbo LDTAldose reductase 1.1.1.21 0.702
3ld5 LDTAldose reductase 1.1.1.21 0.701
3t42 3T4Aldose reductase 1.1.1.21 0.701
3ght LDTAldose reductase 1.1.1.21 0.700
2i16 LDTAldose reductase 1.1.1.21 0.698
2i17 LDTAldose reductase 1.1.1.21 0.698
3mc5 393Aldose reductase 1.1.1.21 0.698
3ghu LDTAldose reductase 1.1.1.21 0.696
2pdh 47DAldose reductase 1.1.1.21 0.693
2ikj 393Aldose reductase 1.1.1.21 0.683
3lql LDTAldose reductase 1.1.1.21 0.683
2pdn 47DAldose reductase 1.1.1.21 0.680
3lz5 LDTAldose reductase 1.1.1.21 0.679
3ghr LDTAldose reductase 1.1.1.21 0.664
2i51 FMNPyridoxamine 5'-phosphate oxidase-related, FMN-binding / 0.654
2inz OHPAldose reductase 1.1.1.21 0.654