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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2hs8 FMN 12-oxophytodienoate reductase 3 1.3.1.42

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 1.302
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 1.270
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 1.242
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 1.217
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 1.167
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 1.113
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 1.063
3p74 FMNPentaerythritol tetranitrate reductase / 1.057
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 1.054
4qnw FMNChanoclavine-I aldehyde reductase easA / 1.015
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.999
4jic FMNGTN Reductase / 0.974
4df2 FMNNADPH dehydrogenase / 0.965
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.949
1h63 FMNPentaerythritol tetranitrate reductase / 0.948
3tjl FMNNADPH dehydrogenase / 0.947
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 0.945
3l5l FMNXenobiotic reductase / 0.945
2h8x FMNXenA / 0.941
5cpm FNRNADH:flavin oxidoreductase / 0.934
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.933
3n14 FMNXenobiotic reductase / 0.932
1vyr FMNPentaerythritol tetranitrate reductase / 0.925
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.924
1z48 FMNNADPH dehydrogenase / 0.914
1z44 FMNNADPH dehydrogenase / 0.911
3hf3 FMNChromate reductase / 0.910
3p62 FMNPentaerythritol tetranitrate reductase / 0.908
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.907
4utm FNRXenobiotic reductase / 0.906
2gqa FMNNADH:flavin oxidoreductase Sye1 / 0.904
3gr8 FMNNADPH dehydrogenase / 0.897
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.896
4utl FNRXenobiotic reductase / 0.893
4tmc FMNOld yellow enzyme / 0.890
4uth FMNXenobiotic reductase / 0.879
4aws FMNNADH:flavin oxidoreductase Sye1 / 0.877
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.876
3n19 FNRXenobiotic reductase / 0.875
3l67 FMNXenobiotic reductase / 0.869
3f03 FMNPentaerythritol tetranitrate reductase / 0.860
4qai FMNNADPH dehydrogenase / 0.860
1h51 FMNPentaerythritol tetranitrate reductase / 0.859
3p8i FMNPentaerythritol tetranitrate reductase / 0.858
4m5p FMNNADPH dehydrogenase / 0.858
1gwj FMNMorphinone reductase / 0.857
2abb FMNPentaerythritol tetranitrate reductase / 0.857
3p84 FMNPentaerythritol tetranitrate reductase / 0.857
3p8j FMNPentaerythritol tetranitrate reductase / 0.857
1h50 FMNPentaerythritol tetranitrate reductase / 0.848
1vhn FMNtRNA-dihydrouridine synthase / 0.843
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.842
4e2d FMNDehydrogenase / 0.835
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 0.826
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 0.824
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 0.824
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 0.818
2djx FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.817
2nli FMNLactate oxidase / 0.815
3atz FMNProstaglandin F2a synthase / 0.815
4e2b FMNDehydrogenase / 0.814
3p67 FMNPentaerythritol tetranitrate reductase / 0.811
1oya FMNNADPH dehydrogenase 1 1.6.99.1 0.809
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.809
2j6x FMNLactate oxidase / 0.807
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.801
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.800
1z41 FMNNADPH dehydrogenase / 0.800
2zfa FMNLactate oxidase / 0.796
3gye FMNDihydroorotate dehydrogenase (fumarate) / 0.790
4tmb FMNOld yellow enzyme / 0.790
1ofd FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.789
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.787
3p82 FMNPentaerythritol tetranitrate reductase / 0.787
2z6i FMN2-nitropropane dioxygenase / 0.775
2zrv FNRIsopentenyl-diphosphate delta-isomerase / 0.771
1kbj FMNCytochrome b2, mitochondrial 1.1.2.3 0.770
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.769
1k02 FMNNADPH dehydrogenase 1 1.6.99.1 0.768
2q3r FMN12-oxophytodienoate reductase 1 1.3.1.42 0.768
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.766
4iql FMNEnoyl-(Acyl-carrier-protein) reductase II / 0.764
4yco FMNtRNA-dihydrouridine(16) synthase / 0.762
2du2 FMNLactate oxidase / 0.759
1kbi FMNCytochrome b2, mitochondrial 1.1.2.3 0.757
2zrz FNRIsopentenyl-diphosphate delta-isomerase / 0.755
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.755
2bsl FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.754
3gka FMNN-ethylmaleimide reductase / 0.749
1h7w FMNDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.744
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 0.742
3vkj FNRIsopentenyl-diphosphate delta-isomerase / 0.740
4yx6 FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.738
1szf FMNCytochrome b2, mitochondrial 1.1.2.3 0.735
2zry FNRIsopentenyl-diphosphate delta-isomerase / 0.731
1lm1 FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.729
1llw FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.728
1fcb FMNCytochrome b2, mitochondrial 1.1.2.3 0.719
4cw5 FMNDfnA / 0.719
1dor FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.715
4xq6 FMNDihydroorotate dehydrogenase (quinone) / 0.712
3aty FMNProstaglandin F2a synthase / 0.711
4z9r FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.709
4rnu FMNNADPH dehydrogenase 1 1.6.99.1 0.704
1ep3 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.700
4rje FNRLactate oxidase / 0.700
2e77 FMNLactate oxidase / 0.697
1djq FMNTrimethylamine dehydrogenase 1.5.8.2 0.695
2djl FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.695
2gjl FMNNitronate monooxygenase 1.13.12.16 0.693
1ea0 FMNGlutamate synthase [NADPH] large chain 1.4.1.13 0.690
2qmy FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.689
2q3o FMN12-oxophytodienoate reductase 3 1.3.1.42 0.688
1llz FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.687
1gg5 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.684
3esz FMNFlavodoxin / 0.683
4yl2 FMNLactate oxidase / 0.680
2gjn FMNNitronate monooxygenase 1.13.12.16 0.678
5ebu FMNLactate oxidase / 0.678
1gox FMNPeroxisomal (S)-2-hydroxy-acid oxidase 1.1.3.15 0.672
1qbg FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.672
3w77 FMNFMN-dependent NADH-azoreductase / 0.672
1owm FADDeoxyribodipyrimidine photo-lyase 4.1.99.3 0.671
1owo FADDeoxyribodipyrimidine photo-lyase 4.1.99.3 0.671
1owp FADDeoxyribodipyrimidine photo-lyase 4.1.99.3 0.671
5bnt NAPAspartate-semialdehyde dehydrogenase 1.2.1.11 0.668
1qr2 FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.667
3oix FMNDihydroorotate dehydrogenase / 0.661
1kbq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.660
1own FADDeoxyribodipyrimidine photo-lyase 4.1.99.3 0.658
2ix5 FADAcyl-coenzyme A oxidase 4, peroxisomal 1.3.3.6 0.656
3qe2 FMNNADPH--cytochrome P450 reductase / 0.656
4gcm NAPThioredoxin reductase 1.8.1.9 0.656
3giy FMN(S)-mandelate dehydrogenase 1.1.99.31 0.655
1iqr FADDeoxyribodipyrimidine photo-lyase 4.1.99.3 0.654
1qcw FNSCytochrome b2, mitochondrial 1.1.2.3 0.654
2vyx FMNDodecin / 0.654
2z9d FMNFMN-dependent NADH-azoreductase / 0.654
2cdu FADNADH oxidase / 0.650