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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2gqa FMN NADH:flavin oxidoreductase Sye1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2gqa FMNNADH:flavin oxidoreductase Sye1 / 1.378
2gou FMNNADH:flavin oxidoreductase Sye1 / 1.298
3l5l FMNXenobiotic reductase / 1.067
1z48 FMNNADPH dehydrogenase / 1.062
2h8x FMNXenA / 1.058
4uth FMNXenobiotic reductase / 1.057
4utm FNRXenobiotic reductase / 1.048
4utk FNRXenobiotic reductase / 1.046
1z41 FMNNADPH dehydrogenase / 1.032
4m5p FMNNADPH dehydrogenase / 1.019
4utl FNRXenobiotic reductase / 1.008
3n14 FMNXenobiotic reductase / 1.003
3tjl FMNNADPH dehydrogenase / 1.002
1z44 FMNNADPH dehydrogenase / 0.985
3hf3 FMNChromate reductase / 0.983
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 0.964
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.963
4qnw FMNChanoclavine-I aldehyde reductase easA / 0.953
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.937
3gr8 FMNNADPH dehydrogenase / 0.926
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.924
1oya FMNNADPH dehydrogenase 1 1.6.99.1 0.919
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.912
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.906
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.905
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.904
1vhn FMNtRNA-dihydrouridine synthase / 0.897
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 0.896
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 0.896
1djq FMNTrimethylamine dehydrogenase 1.5.8.2 0.895
4aws FMNNADH:flavin oxidoreductase Sye1 / 0.893
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 0.887
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 0.879
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 0.874
2nli FMNLactate oxidase / 0.871
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.870
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 0.863
2zfa FMNLactate oxidase / 0.859
3f03 FMNPentaerythritol tetranitrate reductase / 0.857
3p84 FMNPentaerythritol tetranitrate reductase / 0.847
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 0.844
3atz FMNProstaglandin F2a synthase / 0.843
4yl2 FMNLactate oxidase / 0.840
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.839
2bsl FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.838
1vyr FMNPentaerythritol tetranitrate reductase / 0.834
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.834
1h50 FMNPentaerythritol tetranitrate reductase / 0.831
4wzh FMNDihydroorotate dehydrogenase (fumarate) / 0.831
2abb FMNPentaerythritol tetranitrate reductase / 0.822
3p67 FMNPentaerythritol tetranitrate reductase / 0.820
2j6x FMNLactate oxidase / 0.815
2djx FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.814
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.813
2z6i FMN2-nitropropane dioxygenase / 0.810
3c3n FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.809
1dor FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.807
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.805
1h51 FMNPentaerythritol tetranitrate reductase / 0.803
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.802
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.800
3p8j FMNPentaerythritol tetranitrate reductase / 0.799
2djl FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.796
1ofd FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.794
4df2 FMNNADPH dehydrogenase / 0.791
3p62 FMNPentaerythritol tetranitrate reductase / 0.790
4yco FMNtRNA-dihydrouridine(16) synthase / 0.790
4ef9 FMNDihydroorotate dehydrogenase (fumarate) / 0.788
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.786
4xq6 FMNDihydroorotate dehydrogenase (quinone) / 0.786
1kbi FMNCytochrome b2, mitochondrial 1.1.2.3 0.779
1lm1 FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.774
3l67 FMNXenobiotic reductase / 0.771
4yx6 FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.768
4rje FNRLactate oxidase / 0.767
1ep3 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.762
3n19 FNRXenobiotic reductase / 0.762
2zrz FNRIsopentenyl-diphosphate delta-isomerase / 0.761
4iql FMNEnoyl-(Acyl-carrier-protein) reductase II / 0.761
1kbj FMNCytochrome b2, mitochondrial 1.1.2.3 0.758
1ofe FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.758
2du2 FMNLactate oxidase / 0.752
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.745
5cpm FNRNADH:flavin oxidoreductase / 0.744
4e2d FMNDehydrogenase / 0.742
4jic FMNGTN Reductase / 0.737
4tmc FMNOld yellow enzyme / 0.737
2q3o FMN12-oxophytodienoate reductase 3 1.3.1.42 0.736
3gka FMNN-ethylmaleimide reductase / 0.732
3p74 FMNPentaerythritol tetranitrate reductase / 0.732
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 0.716
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.712
1vcf FMNIsopentenyl-diphosphate delta-isomerase / 0.710
4z9r FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.709
4rnu FMNNADPH dehydrogenase 1 1.6.99.1 0.703
4e2b FMNDehydrogenase / 0.702
3b04 OOPIsopentenyl-diphosphate delta-isomerase / 0.698
4nmc FADBifunctional protein PutA / 0.696
4z38 FMNMlnA / 0.696
2zrx FMNIsopentenyl-diphosphate delta-isomerase / 0.694
3giy FMN(S)-mandelate dehydrogenase 1.1.99.31 0.694
3p82 FMNPentaerythritol tetranitrate reductase / 0.694
1uum FMNDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.692
4tmb FMNOld yellow enzyme / 0.692
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 0.691
1dxq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.691
1llz FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.686
3aty FMNProstaglandin F2a synthase / 0.680
3b05 FNRIsopentenyl-diphosphate delta-isomerase / 0.680
3n39 FMNProtein NrdI / 0.679
2zrv FNRIsopentenyl-diphosphate delta-isomerase / 0.677
4cw5 FMNDfnA / 0.677
2zry FNRIsopentenyl-diphosphate delta-isomerase / 0.676
3qfr FMNNADPH--cytochrome P450 reductase / 0.675
4qoe FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.674
4qof FMNRibosyldihydronicotinamide dehydrogenase [quinone] / 0.673
1gwj FMNMorphinone reductase / 0.672
1h63 FMNPentaerythritol tetranitrate reductase / 0.672
3esz FMNFlavodoxin / 0.672
3qe2 FMNNADPH--cytochrome P450 reductase / 0.671
2gjn FMNNitronate monooxygenase 1.13.12.16 0.670
2ohj FMNType A flavoprotein FprA 1 0.669
4wct FADFructosyl amine:oxygen oxidoreductase / 0.664
1nb9 RBFRiboflavin kinase 2.7.1.26 0.662
4ef8 FMNDihydroorotate dehydrogenase (fumarate) / 0.662
1k02 FMNNADPH dehydrogenase 1 1.6.99.1 0.661
2q3r FMN12-oxophytodienoate reductase 1 1.3.1.42 0.660
4ttc FMNIodotyrosine deiodinase 1 / 0.660
3n3b FMNProtein NrdI / 0.658
3p8i FMNPentaerythritol tetranitrate reductase / 0.658
4bby FADAlkyldihydroxyacetonephosphate synthase, peroxisomal 2.5.1.26 0.658
4h6r FDAProline dehydrogenase / 0.658
3w77 FMNFMN-dependent NADH-azoreductase / 0.655
1d4a FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.654
1siq FADGlutaryl-CoA dehydrogenase, mitochondrial 1.3.8.6 0.653
3n3a FMNProtein NrdI / 0.652
4i6g FADCryptochrome-2 / 0.652
4nmb FADBifunctional protein PutA / 0.652
1own FADDeoxyribodipyrimidine photo-lyase 4.1.99.3 0.651
1llw FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.650
1qr2 FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.650
2fcr FMNFlavodoxin / 0.650