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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2g86 UMP Thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2g86 UMPThymidylate synthase / 1.021
2g8d UMPThymidylate synthase / 0.916
2g8a UMPThymidylate synthase / 0.854
1j3j UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.846
1tsy UMPThymidylate synthase / 0.836
3dg8 UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.829
1f28 UMPThymidylate synthase 2.1.1.45 0.825
2tdm UMPThymidylate synthase / 0.823
4dpd UMPBifunctional dihydrofolate reductase-thymidylate synthase / 0.823
1bid UMPThymidylate synthase / 0.820
5by6 UMPThymidylate synthase / 0.818
2fto TMPThymidylate synthase / 0.817
2g89 UMPThymidylate synthase / 0.813
3dga UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.810
4e5o UMPThymidylate synthase 2.1.1.45 0.809
1tsv UMPThymidylate synthase / 0.808
1bp0 UMPThymidylate synthase / 0.796
1nja DCMThymidylate synthase / 0.796
1bp6 UMPThymidylate synthase / 0.795
1tsx UMPThymidylate synthase / 0.790
2tsr UMPThymidylate synthase 2.1.1.45 0.784
4fox UMPThymidylate synthase ThyA / 0.775
4dq1 UMPThymidylate synthase / 0.774
1b5d DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.761
3bgx TMPThymidylate synthase / 0.758
4eb4 UMPThymidylate synthase 2.1.1.45 0.749
4ein NOHThymidylate synthase 2.1.1.45 0.749
1vzb UMPThymidylate synthase / 0.745
1njc DCMThymidylate synthase / 0.740
2vet UMPThymidylate synthase / 0.736
1jmf UMPThymidylate synthase / 0.735
4irr UMPThymidylate synthase / 0.726
1njd UMPThymidylate synthase / 0.723
1b5e DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.722
1vza UMPThymidylate synthase / 0.722
4isk UMPThymidylate synthase / 0.720
3qj7 UMPThymidylate synthase ThyA / 0.715
1bpj UMPThymidylate synthase / 0.713
1jmh UMPThymidylate synthase / 0.700
4eil UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.696
1nje DCMThymidylate synthase / 0.692
4if5 ACOAlpha-tubulin N-acetyltransferase 1 / 0.689
1thy UMPThymidylate synthase / 0.688
4iqq UMPThymidylate synthase / 0.678
4psg NOHThymidylate synthase / 0.676
4xsd UMPThymidylate synthase 2.1.1.45 0.676
1tys TMPThymidylate synthase / 0.674
4hs4 FMNChromate reductase / 0.674
3l5l FMNXenobiotic reductase / 0.673
4uth FMNXenobiotic reductase / 0.673
4utm FNRXenobiotic reductase / 0.673
1jmg UMPThymidylate synthase / 0.666
1jmi UMPThymidylate synthase / 0.663
1tdc UMPThymidylate synthase / 0.663
3qft NAPNADPH--cytochrome P450 reductase / 0.659
4h0u UMPThymidylate synthase / 0.659
1djl NAPNAD(P) transhydrogenase, mitochondrial 1.6.1.2 0.658
3qfs NAPNADPH--cytochrome P450 reductase / 0.658
1fnd A2PFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.657
4gcm NAPThioredoxin reductase 1.8.1.9 0.654