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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2fz9 ZST Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2fz9 ZSTAldose reductase 1.1.1.21 1.197
2hv5 ZSTAldose reductase 1.1.1.21 1.144
2duz ZSTAldose reductase 1.1.1.21 1.132
2fz8 ZSTAldose reductase 1.1.1.21 1.111
2hvn ZSTAldose reductase 1.1.1.21 1.089
2pdi ZSTAldose reductase 1.1.1.21 1.072
2hvo ZSTAldose reductase 1.1.1.21 1.061
2dv0 ZSTAldose reductase 1.1.1.21 1.056
3len ZSTAldose reductase 1.1.1.21 1.054
2pdm ZSTAldose reductase 1.1.1.21 1.044
2pdb ZSTAldose reductase 1.1.1.21 1.009
3mb9 ZSTAldose reductase 1.1.1.21 1.009
2pdx ZSTAldose reductase 1.1.1.21 0.997
3m0i ZSTAldose reductase 1.1.1.21 0.996
2pdn 47DAldose reductase 1.1.1.21 0.958
3g5e Q74Aldose reductase 1.1.1.21 0.909
2pdq 47DAldose reductase 1.1.1.21 0.883
1frb ZSTAldose reductase-related protein 2 / 0.876
2pd5 ZSTAldose reductase 1.1.1.21 0.873
1z3n 3NAAldose reductase 1.1.1.21 0.871
4gca 2X9Aldose reductase 1.1.1.21 0.860
2pdf ZSTAldose reductase 1.1.1.21 0.833
2dux ZSTAldose reductase 1.1.1.21 0.816
2pdg 47DAldose reductase 1.1.1.21 0.796
2pdp 393Aldose reductase 1.1.1.21 0.787
2pdj 393Aldose reductase 1.1.1.21 0.786
2pdu 393Aldose reductase 1.1.1.21 0.769
2pdh 47DAldose reductase 1.1.1.21 0.753
3ld5 LDTAldose reductase 1.1.1.21 0.753
3lbo LDTAldose reductase 1.1.1.21 0.749
3m64 393Aldose reductase 1.1.1.21 0.744
3lql LDTAldose reductase 1.1.1.21 0.743
1t40 ID5Aldose reductase 1.1.1.21 0.737
3m4h 388Aldose reductase 1.1.1.21 0.717
2pzn 393Aldose reductase 1.1.1.21 0.713
3lz5 LDTAldose reductase 1.1.1.21 0.698
3mc5 393Aldose reductase 1.1.1.21 0.698
2pdc 393Aldose reductase 1.1.1.21 0.697
1t41 ID5Aldose reductase 1.1.1.21 0.691
2ikj 393Aldose reductase 1.1.1.21 0.683
1iei ZESAldose reductase 1.1.1.21 0.679
3ghr LDTAldose reductase 1.1.1.21 0.678
3ghs LDTAldose reductase 1.1.1.21 0.678
2ikh LITAldose reductase 1.1.1.21 0.672
2i17 LDTAldose reductase 1.1.1.21 0.668
2qxw LDTAldose reductase 1.1.1.21 0.668
1z89 62PAldose reductase 1.1.1.21 0.656