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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2fz8 ZST Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2fz8 ZSTAldose reductase 1.1.1.21 1.293
2hvn ZSTAldose reductase 1.1.1.21 1.205
2pdi ZSTAldose reductase 1.1.1.21 1.182
2duz ZSTAldose reductase 1.1.1.21 1.181
2hvo ZSTAldose reductase 1.1.1.21 1.171
3len ZSTAldose reductase 1.1.1.21 1.129
2hv5 ZSTAldose reductase 1.1.1.21 1.122
2pdb ZSTAldose reductase 1.1.1.21 1.117
2fz9 ZSTAldose reductase 1.1.1.21 1.111
3m0i ZSTAldose reductase 1.1.1.21 1.085
2dv0 ZSTAldose reductase 1.1.1.21 1.027
3mb9 ZSTAldose reductase 1.1.1.21 1.019
2pdx ZSTAldose reductase 1.1.1.21 0.974
2pdq 47DAldose reductase 1.1.1.21 0.926
2dux ZSTAldose reductase 1.1.1.21 0.898
2pdm ZSTAldose reductase 1.1.1.21 0.892
2pd5 ZSTAldose reductase 1.1.1.21 0.885
1z3n 3NAAldose reductase 1.1.1.21 0.867
4gca 2X9Aldose reductase 1.1.1.21 0.839
2pdf ZSTAldose reductase 1.1.1.21 0.812
1frb ZSTAldose reductase-related protein 2 / 0.806
2pdp 393Aldose reductase 1.1.1.21 0.793
3m4h 388Aldose reductase 1.1.1.21 0.777
3ghr LDTAldose reductase 1.1.1.21 0.775
3ghs LDTAldose reductase 1.1.1.21 0.775
3g5e Q74Aldose reductase 1.1.1.21 0.771
2pdg 47DAldose reductase 1.1.1.21 0.768
1t40 ID5Aldose reductase 1.1.1.21 0.757
2pdj 393Aldose reductase 1.1.1.21 0.753
2pdu 393Aldose reductase 1.1.1.21 0.749
1us0 LDTAldose reductase 1.1.1.21 0.741
3t42 3T4Aldose reductase 1.1.1.21 0.740
3lql LDTAldose reductase 1.1.1.21 0.725
3lbo LDTAldose reductase 1.1.1.21 0.711
2pdh 47DAldose reductase 1.1.1.21 0.709
2inz OHPAldose reductase 1.1.1.21 0.706
3ld5 LDTAldose reductase 1.1.1.21 0.698
3m64 393Aldose reductase 1.1.1.21 0.697
2pdn 47DAldose reductase 1.1.1.21 0.695
2ikj 393Aldose reductase 1.1.1.21 0.682
2pdc 393Aldose reductase 1.1.1.21 0.667
2pzn 393Aldose reductase 1.1.1.21 0.667
1t41 ID5Aldose reductase 1.1.1.21 0.663
3mc5 393Aldose reductase 1.1.1.21 0.662
3lz5 LDTAldose reductase 1.1.1.21 0.661
4a16 H34Acetylcholinesterase 3.1.1.7 0.655