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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2en5 SAH Diphthine synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2en5 SAHDiphthine synthase / 1.119
2eh4 SAHDiphthine synthase / 1.116
2ek4 SAHDiphthine synthase / 1.114
2pb5 SAHDiphthine synthase / 1.114
2pcg SAHDiphthine synthase / 1.114
2e8r SAHDiphthine synthase / 1.113
2e8s SAHDiphthine synthase / 1.113
2el3 SAHDiphthine synthase / 1.113
2emr SAHDiphthine synthase / 1.113
2eh5 SAHDiphthine synthase / 1.112
2eka SAHDiphthine synthase / 1.112
2pb6 SAHDiphthine synthase / 1.109
2e4n SAHDiphthine synthase / 1.098
2dxx SAHDiphthine synthase / 1.097
2ek7 SAHDiphthine synthase / 1.097
2dv3 SAHDiphthine synthase / 1.096
2ed5 SAHDiphthine synthase / 1.096
2ele SAHDiphthine synthase / 1.096
2p9d SAHDiphthine synthase / 1.096
2pca SAHDiphthine synthase / 1.096
2eld SAHDiphthine synthase / 1.094
2p6l SAHDiphthine synthase / 1.094
2ek2 SAHDiphthine synthase / 1.093
2eni SAHDiphthine synthase / 1.093
2p5f SAHDiphthine synthase / 1.093
2p6k SAHDiphthine synthase / 1.093
2pcm SAHDiphthine synthase / 1.093
2p6d SAHDiphthine synthase / 1.091
2ek3 SAHDiphthine synthase / 1.090
2owg SAHDiphthine synthase / 1.089
2dxw SAHDiphthine synthase / 1.078
2egs SAHDiphthine synthase / 1.077
2eh2 SAHDiphthine synthase / 1.077
2pch SAHDiphthine synthase / 1.077
2pck SAHDiphthine synthase / 1.077
2e08 SAHDiphthine synthase / 1.076
2owk SAHDiphthine synthase / 1.076
2dv5 SAHDiphthine synthase / 1.075
2e17 SAHDiphthine synthase / 1.075
2e8h SAHDiphthine synthase / 1.075
2el0 SAHDiphthine synthase / 1.075
2p6i SAHDiphthine synthase / 1.075
1wng SAHDiphthine synthase / 1.074
2huq SAHDiphthine synthase / 1.074
2huv SAHDiphthine synthase / 1.074
2pb4 SAHDiphthine synthase / 1.074
2eeq SAHDiphthine synthase / 1.072
2emu SAHDiphthine synthase / 1.071
2p5c SAHDiphthine synthase / 1.069
2owv SAHDiphthine synthase / 1.066
2ejk SAHDiphthine synthase / 1.062
2dxv SAHDiphthine synthase / 1.060
2e07 SAHDiphthine synthase / 1.060
2e7r SAHDiphthine synthase / 1.060
2ehl SAHDiphthine synthase / 1.060
2z6r SAHDiphthine synthase / 1.060
2e8q SAHDiphthine synthase / 1.059
2egb SAHDiphthine synthase / 1.059
2egl SAHDiphthine synthase / 1.058
2ejj SAHDiphthine synthase / 1.058
2e15 SAHDiphthine synthase / 1.057
2dek SAHDiphthine synthase / 1.056
2dsg SAHDiphthine synthase / 1.056
2dsh SAHDiphthine synthase / 1.056
2dv7 SAHDiphthine synthase / 1.056
2e16 SAHDiphthine synthase / 1.055
2owu SAHDiphthine synthase / 1.054
2hut SAHDiphthine synthase / 1.051
2p2x SAHDiphthine synthase / 1.045
2pci SAHDiphthine synthase / 1.041
2dsi SAHDiphthine synthase / 1.040
2dv4 SAHDiphthine synthase / 1.038
1vce SAHDiphthine synthase / 1.037
2hux SAHDiphthine synthase / 0.947
2hr8 SAHDiphthine synthase / 0.888
2owf SAHDiphthine synthase / 0.745
2ejz SAHDiphthine synthase / 0.722
2e0n SAHPrecorrin-2 C20-methyltransferase / 0.706
2ed3 SAHDiphthine synthase / 0.705
1cbf SAHCobalt-precorrin-4 C(11)-methyltransferase 2.1.1.271 0.690
1jgt APCCarboxyethyl-arginine beta-lactam-synthase 6.3.3.4 0.682
3s3t ATPUniversal stress protein / 0.679
2ha8 SAHProbable methyltransferase TARBP1 / 0.673
4rrm A3TProbable threonine--tRNA ligase 2 6.1.1.3 0.673
2ybo SAHMethyltransferase / 0.667
1s4d SAHUroporphyrinogen-III C-methyltransferase 2.1.1.107 0.665
1kh2 ATPArgininosuccinate synthase / 0.664
5a7y SAHtRNA (adenine(9)-N1)-methyltransferase 2.1.1.218 0.664
3nut SAHPrecorrin-3 methylase / 0.662
2egw SAHRibosomal RNA small subunit methyltransferase E 2.1.1.193 0.661
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.661
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
2zvc SAHPrecorrin-3 C17-methyltransferase / 0.659
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.659
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.658
1id0 ANPSensor protein PhoQ 2.7.13.3 0.657
3ndc SAHPrecorrin-4 C(11)-methyltransferase 2.1.1.133 0.656
2bb3 SAHCobalamin biosynthesis precorrin-6Y methylase (CbiE) / 0.655
4jl8 ADPAdenylate kinase / 0.654
4rr6 A3SProbable threonine--tRNA ligase 2 6.1.1.3 0.653
4rrb A3TProbable threonine--tRNA ligase 2 6.1.1.3 0.653
4rrl A3SProbable threonine--tRNA ligase 2 6.1.1.3 0.653
4rr8 A3SProbable threonine--tRNA ligase 2 6.1.1.3 0.651
4rrh A3SProbable threonine--tRNA ligase 2 6.1.1.3 0.650