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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2egb SAH Diphthine synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2egb SAHDiphthine synthase / 1.088
2e07 SAHDiphthine synthase / 1.085
2e7r SAHDiphthine synthase / 1.085
2egl SAHDiphthine synthase / 1.085
2dxw SAHDiphthine synthase / 1.084
2ehl SAHDiphthine synthase / 1.084
2e15 SAHDiphthine synthase / 1.083
2z6r SAHDiphthine synthase / 1.083
2dek SAHDiphthine synthase / 1.079
2el0 SAHDiphthine synthase / 1.078
2owk SAHDiphthine synthase / 1.078
2owu SAHDiphthine synthase / 1.074
2dxv SAHDiphthine synthase / 1.067
2dsg SAHDiphthine synthase / 1.065
2dxx SAHDiphthine synthase / 1.065
2dsh SAHDiphthine synthase / 1.064
2dv7 SAHDiphthine synthase / 1.064
2e08 SAHDiphthine synthase / 1.064
2eh2 SAHDiphthine synthase / 1.064
2e17 SAHDiphthine synthase / 1.063
2e4n SAHDiphthine synthase / 1.063
2egs SAHDiphthine synthase / 1.063
2ek7 SAHDiphthine synthase / 1.063
2ele SAHDiphthine synthase / 1.063
2e16 SAHDiphthine synthase / 1.062
2ejj SAHDiphthine synthase / 1.062
2eni SAHDiphthine synthase / 1.062
2p9d SAHDiphthine synthase / 1.062
2ed5 SAHDiphthine synthase / 1.061
2p6i SAHDiphthine synthase / 1.061
2p6k SAHDiphthine synthase / 1.061
2hut SAHDiphthine synthase / 1.060
2p6l SAHDiphthine synthase / 1.060
2pcm SAHDiphthine synthase / 1.060
2dv3 SAHDiphthine synthase / 1.059
2eh4 SAHDiphthine synthase / 1.059
2en5 SAHDiphthine synthase / 1.059
2p5f SAHDiphthine synthase / 1.059
2pca SAHDiphthine synthase / 1.059
2pcg SAHDiphthine synthase / 1.059
2pck SAHDiphthine synthase / 1.059
1wng SAHDiphthine synthase / 1.058
2e8s SAHDiphthine synthase / 1.058
2ek3 SAHDiphthine synthase / 1.058
2ek4 SAHDiphthine synthase / 1.058
2emr SAHDiphthine synthase / 1.058
2e8r SAHDiphthine synthase / 1.057
2ek2 SAHDiphthine synthase / 1.057
2eld SAHDiphthine synthase / 1.057
2pb5 SAHDiphthine synthase / 1.057
2dv5 SAHDiphthine synthase / 1.056
2eeq SAHDiphthine synthase / 1.056
2eh5 SAHDiphthine synthase / 1.056
2eka SAHDiphthine synthase / 1.056
2el3 SAHDiphthine synthase / 1.056
2huq SAHDiphthine synthase / 1.056
2huv SAHDiphthine synthase / 1.056
2pb6 SAHDiphthine synthase / 1.055
2ejk SAHDiphthine synthase / 1.053
2pci SAHDiphthine synthase / 1.053
2p6d SAHDiphthine synthase / 1.046
2pch SAHDiphthine synthase / 1.043
2dv4 SAHDiphthine synthase / 1.042
2dsi SAHDiphthine synthase / 1.040
2emu SAHDiphthine synthase / 1.040
2owv SAHDiphthine synthase / 1.038
2e8h SAHDiphthine synthase / 1.037
2owg SAHDiphthine synthase / 1.037
1vce SAHDiphthine synthase / 1.035
2p5c SAHDiphthine synthase / 1.034
2pb4 SAHDiphthine synthase / 1.034
2e8q SAHDiphthine synthase / 1.024
2p2x SAHDiphthine synthase / 1.017
2hux SAHDiphthine synthase / 0.944
2hr8 SAHDiphthine synthase / 0.884
2ejz SAHDiphthine synthase / 0.759
2ed3 SAHDiphthine synthase / 0.706
2egv SAMRibosomal RNA small subunit methyltransferase E 2.1.1.193 0.705
3ndc SAHPrecorrin-4 C(11)-methyltransferase 2.1.1.133 0.704
2owf SAHDiphthine synthase / 0.696
1cbf SAHCobalt-precorrin-4 C(11)-methyltransferase 2.1.1.271 0.691
1jgt APCCarboxyethyl-arginine beta-lactam-synthase 6.3.3.4 0.686
2ha8 SAHProbable methyltransferase TARBP1 / 0.686
3s3t ATPUniversal stress protein / 0.683
5a7y SAHtRNA (adenine(9)-N1)-methyltransferase 2.1.1.218 0.679
1i44 ACPInsulin receptor 2.7.10.1 0.668
1s4d SAHUroporphyrinogen-III C-methyltransferase 2.1.1.107 0.668
1euy QSIGlutamine--tRNA ligase 6.1.1.18 0.663
2ybo SAHMethyltransferase / 0.663
2egw SAHRibosomal RNA small subunit methyltransferase E 2.1.1.193 0.661
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
3n4k SAHtRNA (cytidine(34)-2'-O)-methyltransferase / 0.659
2zvc SAHPrecorrin-3 C17-methyltransferase / 0.658
2qbu SAHPrecorrin-2 methyltransferase / 0.657
2zvb SAHPrecorrin-3 C17-methyltransferase / 0.656
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.656
4qny ANPMitogen activated protein kinase, putative / 0.656
1qrs ATPGlutamine--tRNA ligase 6.1.1.18 0.652
2e0n SAHPrecorrin-2 C20-methyltransferase / 0.652
4rr8 A3SProbable threonine--tRNA ligase 2 6.1.1.3 0.652
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.650