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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2cn0 F25 Prothrombin 3.4.21.5

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2cn0 F25Prothrombin 3.4.21.5 1.097
2cf8 ESHProthrombin 3.4.21.5 0.981
2cf9 348Prothrombin 3.4.21.5 0.917
1ype UIPProthrombin 3.4.21.5 0.910
1oyt FSNProthrombin 3.4.21.5 0.907
1vzq SHYProthrombin 3.4.21.5 0.886
1ypg UIRProthrombin 3.4.21.5 0.838
4ax9 N5NProthrombin 3.4.21.5 0.802
1ypj UIBProthrombin 3.4.21.5 0.757
2zfq 45UProthrombin 3.4.21.5 0.756
2zhw 12UProthrombin 3.4.21.5 0.756
2zhq 27UProthrombin 3.4.21.5 0.754
2bok 784Coagulation factor X 3.4.21.6 0.751
4az2 9MUProthrombin 3.4.21.5 0.750
4ayv 9MQProthrombin 3.4.21.5 0.748
5cmx 0G6Prothrombin 3.4.21.5 0.748
1ypm RA4Prothrombin 3.4.21.5 0.747
2zgx 29UProthrombin 3.4.21.5 0.747
2ziq 26UProthrombin 3.4.21.5 0.746
1ypk CCRProthrombin 3.4.21.5 0.745
4ban M6SProthrombin 3.4.21.5 0.745
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
2znk 31UProthrombin 3.4.21.5 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4bah MELProthrombin 3.4.21.5 0.742
2zi2 24UProthrombin 3.4.21.5 0.741
4bao MVFProthrombin 3.4.21.5 0.741
2zda 32UProthrombin 3.4.21.5 0.740
2zfr 46UProthrombin 3.4.21.5 0.734
1k21 IGNProthrombin 3.4.21.5 0.733
3utu 1TSProthrombin 3.4.21.5 0.733
2zg0 50UProthrombin 3.4.21.5 0.730
4ayy 9MXProthrombin 3.4.21.5 0.729
4bak M67Prothrombin 3.4.21.5 0.724
2bdy UNBProthrombin 3.4.21.5 0.722
2zhe 13UProthrombin 3.4.21.5 0.720
3hat GLY_VAL_ARG_RNGProthrombin 3.4.21.5 0.719
1k22 MELProthrombin 3.4.21.5 0.718
1d4p BPPProthrombin 3.4.21.5 0.717
3plp BBACationic trypsin 3.4.21.4 0.717
1nzq 162Prothrombin 3.4.21.5 0.716
4bam MM9Prothrombin 3.4.21.5 0.714
1c4v IH2Prothrombin 3.4.21.5 0.711
4baq M4ZProthrombin 3.4.21.5 0.711
3biv 11UProthrombin 3.4.21.5 0.704
7kme ACE_0BN_CHG_PRRProthrombin 3.4.21.5 0.701
2zhf 49UProthrombin 3.4.21.5 0.699
1ghv 120Prothrombin 3.4.21.5 0.696
1lpk CBBCoagulation factor X 3.4.21.6 0.693
1ae8 AZLProthrombin 3.4.21.5 0.680
2a2x NA9Prothrombin 3.4.21.5 0.677
3biu 10UProthrombin 3.4.21.5 0.670
1c1u BAIProthrombin 3.4.21.5 0.666
4fue 7UPUrokinase-type plasminogen activator 3.4.21.73 0.665
2v3o I26Prothrombin 3.4.21.5 0.663
1ypl RA8Prothrombin 3.4.21.5 0.660
4e5f 0N7Polymerase acidic protein / 0.660
1afe ALZProthrombin 3.4.21.5 0.653
1kts C24Prothrombin 3.4.21.5 0.653
2anm CDOProthrombin 3.4.21.5 0.653
1riw OSCProthrombin 3.4.21.5 0.652
1t4v 14AProthrombin 3.4.21.5 0.652
1c4u IH1Prothrombin 3.4.21.5 0.651
1mu8 CDBProthrombin 3.4.21.5 0.650