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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2clq STU Mitogen-activated protein kinase kinase kinase 5 2.7.11.25

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 1.106
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.922
1xjd STUProtein kinase C theta type 2.7.11.13 0.903
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.881
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.858
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.832
4yzc STUSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.827
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.821
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.819
1nvs UCMSerine/threonine-protein kinase Chk1 2.7.11.1 0.809
1nxk STUMAP kinase-activated protein kinase 2 2.7.11.1 0.800
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.793
4kik KSAInhibitor of nuclear factor kappa-B kinase subunit beta 2.7.11.10 0.792
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.790
1byg STUTyrosine-protein kinase CSK / 0.781
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.777
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.764
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.761
2j0k 4STFocal adhesion kinase 1 2.7.10.2 0.758
5e8x STUTGF-beta receptor type-1 2.7.11.30 0.747
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.743
4mvf STUCalcium-dependent protein kinase 2 2.7.11.1 0.739
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.738
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.737
2j0m 4STFocal adhesion kinase 1 2.7.10.2 0.732
4wsq KSAAP2-associated protein kinase 1 2.7.11.1 0.731
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.726
3a4o STUTyrosine-protein kinase Lyn 2.7.10.2 0.722
3zew STUEphrin type-B receptor 4 2.7.10.1 0.716
3ckx STUSerine/threonine-protein kinase 24 2.7.11.1 0.712
4erw STUCyclin-dependent kinase 2 2.7.11.22 0.709
1q3d STUGlycogen synthase kinase-3 beta 2.7.11.26 0.703
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.703
1snu STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.702
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.699
4bib IEOMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.695
1stc STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.686
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 0.682
3cxw 7CPSerine/threonine-protein kinase pim-1 2.7.11.1 0.675
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.671
4ivw 1GJEstrogen receptor / 0.670
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.668
3pcf FHBProtocatechuate 3,4-dioxygenase beta chain 1.13.11.3 0.668
4qmy STUSerine/threonine-protein kinase 24 2.7.11.1 0.668
3nuy JPZ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.665
3mcy ZH1FimH / 0.661
4e5f 0N7Polymerase acidic protein / 0.660
4bid IE8Mitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.656
2gnh H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
3qcy 3Q33-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.654
3r1y X76Cyclin-dependent kinase 2 2.7.11.22 0.652
4fk6 0UJTyrosine-protein kinase JAK1 / 0.651
3qcx 3Q23-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.650