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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2c3l IDZ Serine/threonine-protein kinase Chk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2c3l IDZSerine/threonine-protein kinase Chk1 2.7.11.1 0.814
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.726
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.711
3lfn A27Cyclin-dependent kinase 2 2.7.11.22 0.668
2hxq 373Serine/threonine-protein kinase Chk1 2.7.11.1 0.666
2w1d L0DAurora kinase A 2.7.11.1 0.661
3lfq A28Cyclin-dependent kinase 2 2.7.11.22 0.661
3zly YSODual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.661
4e5f 0N7Polymerase acidic protein / 0.660
3lfs A07Cyclin-dependent kinase 2 2.7.11.22 0.655
4e5l DBHPolymerase acidic protein / 0.655
1ydr IQPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
4ag8 AXIVascular endothelial growth factor receptor 2 2.7.10.1 0.653
3w1f 1O5Dual specificity protein kinase TTK 2.7.12.1 0.652