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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2abi 1CA Mineralocorticoid receptor

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2abi 1CAMineralocorticoid receptor / 1.128
2aa7 1CAMineralocorticoid receptor / 1.034
2aa2 AS4Mineralocorticoid receptor / 0.957
2aax PDNMineralocorticoid receptor / 0.922
2aa6 STRMineralocorticoid receptor / 0.878
1y9r 1CAMineralocorticoid receptor / 0.860
1ya3 STRMineralocorticoid receptor / 0.816
3vhu SNLMineralocorticoid receptor / 0.815
4uda DEXMineralocorticoid receptor / 0.814
2oax SNLMineralocorticoid receptor / 0.775
2ab2 SNLMineralocorticoid receptor / 0.774
2w8y 486Progesterone receptor / 0.757
3mne DEXGlucocorticoid receptor / 0.748
1sqn NDRProgesterone receptor / 0.745
4a2j AS0Progesterone receptor / 0.743
2aa5 STRMineralocorticoid receptor / 0.741
1sr7 MOFProgesterone receptor / 0.739
2w8y NDRProgesterone receptor / 0.738
3d90 NOGProgesterone receptor / 0.730
1p93 DEXGlucocorticoid receptor / 0.726
2ovh AS0Progesterone receptor / 0.718
4p6x HCYGlucocorticoid receptor / 0.715
3mno DEXGlucocorticoid receptor / 0.710
1m2z DEXGlucocorticoid receptor / 0.708
3iw1 ASDSteroid C26-monooxygenase 1.14.13.141 0.706
2qpy DHTAndrogen receptor / 0.704
1gs4 ZK5Androgen receptor / 0.703
3mnp DEXGlucocorticoid receptor / 0.702
4oed DHTAndrogen receptor / 0.699
2piw DHTAndrogen receptor / 0.693
2pkl DHTAndrogen receptor / 0.692
2ovm AS0Progesterone receptor / 0.691
1p8d CO1Oxysterols receptor LXR-beta / 0.685
3uzz ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.685
2j7x ESTEstrogen receptor beta / 0.677
1kdm DHTSex hormone-binding globulin / 0.670
3zqt TESAndrogen receptor / 0.670
1lnm DTXBilin-binding protein / 0.669
1t79 DHTAndrogen receptor / 0.669
1lke DOGBilin-binding protein / 0.667
3cmf PDN3-oxo-5-beta-steroid 4-dehydrogenase / 0.666
1t76 DHTAndrogen receptor / 0.665
1t7f DHTAndrogen receptor / 0.665
1t7m DHTAndrogen receptor / 0.665
2ama DHTAndrogen receptor / 0.664
1jtv TESEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.663
3k9v CPS1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial / 0.661
4udc DEXGlucocorticoid receptor / 0.661
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.660
4e5i 0N9Polymerase acidic protein / 0.660
2qd4 CHDFerrochelatase, mitochondrial 4.99.1.1 0.659
4j6b PLOCytochrome P450 monooxygenase / 0.659
4klr CHDFerrochelatase, mitochondrial 4.99.1.1 0.658
4p6w MOFGlucocorticoid receptor / 0.658
3g1r FIT3-oxo-5-beta-steroid 4-dehydrogenase / 0.655
4e5f 0N7Polymerase acidic protein / 0.655
2rlc CHDCholoylglycine hydrolase 3.5.1.24 0.654
5dx3 ESTEstrogen receptor / 0.653
2hrc CHDFerrochelatase, mitochondrial 4.99.1.1 0.652
2q7l TESAndrogen receptor / 0.652
3cot STR3-oxo-5-beta-steroid 4-dehydrogenase / 0.651
2mm3 GCHGastrotropin / 0.650