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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2aa3 AP0 L-lactate dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2aa3 AP0L-lactate dehydrogenase / 1.039
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.934
1sow NADL-lactate dehydrogenase 1.1.1.27 0.906
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.905
1pzg A3DLactate dehydrogenase / 0.897
1pzf A3DLactate dehydrogenase / 0.880
2a92 NAIL-lactate dehydrogenase / 0.874
1pzh NADLactate dehydrogenase / 0.869
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.860
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.855
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.836
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.824
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.789
4ros APRMalate dehydrogenase / 0.769
4i1i NADMalate dehydrogenase / 0.767
1gv0 NADMalate dehydrogenase / 0.766
1ib6 NADMalate dehydrogenase / 0.762
1wze NADMalate dehydrogenase / 0.760
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.756
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.752
1psd NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.741
1bdm NAXMalate dehydrogenase / 0.738
1b8v NADMalate dehydrogenase / 0.735
1bmd NADMalate dehydrogenase / 0.734
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.734
3gvh NADMalate dehydrogenase / 0.733
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.729
1uxk NADMalate dehydrogenase / 0.725
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.723
2x0i NAIMalate dehydrogenase / 0.721
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.721
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.715
1y7t NDPMalate dehydrogenase / 0.713
3gvi ADPMalate dehydrogenase / 0.711
1e6w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.710
3kb6 NADD-lactate dehydrogenase / 0.706
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.706
1dxy NADD-2-hydroxyisocaproate dehydrogenase 1.1.1 0.704
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.703
2yy7 NADL-threonine dehydrogenase / 0.702
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.702
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.701
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.701
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.699
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.699
1h2h NADL-aspartate dehydrogenase 1.4.1.21 0.698
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.696
1b8u NADMalate dehydrogenase / 0.692
2d8a NADL-threonine 3-dehydrogenase / 0.692
3qvx NADMyo-inositol-1-phosphate synthase (Ino1) / 0.692
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.691
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.690
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.690
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.690
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.690
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.690
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.689
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.687
4z0p NDPNAD-dependent dehydrogenase / 0.685
1uxj NADMalate dehydrogenase / 0.684
2voj NADAlanine dehydrogenase 1.4.1.1 0.684
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.684
2o4c NADErythronate-4-phosphate dehydrogenase / 0.683
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.683
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.683
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.682
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.681
3h3f NAIL-lactate dehydrogenase A chain 1.1.1.27 0.681
4j43 NADUncharacterized protein / 0.681
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.680
1o6z NADMalate dehydrogenase / 0.679
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.679
2hu2 NADC-terminal binding protein 1 / 0.679
1szj NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.678
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.678
3pqf NADL-lactate dehydrogenase 1.1.1.27 0.677
3rua NADUDP-N-acetylglucosamine 4-epimerase / 0.677
1ie3 NADMalate dehydrogenase / 0.675
2pa3 NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.675
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.675
5lc1 NADL-threonine 3-dehydrogenase / 0.674
1u7h NADPutative ornithine cyclodeaminase / 0.673
1guy NADMalate dehydrogenase / 0.672
3ggp NADPrephenate dehydrogenase / 0.672
1x7d NADPutative ornithine cyclodeaminase / 0.671
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.671
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.671
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.670
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.670
3qvs NADMyo-inositol-1-phosphate synthase (Ino1) / 0.670
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.669
3nt4 NAIInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.669
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.668
2ome NADC-terminal-binding protein 2 / 0.667
4c4o NADSADH / 0.667
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.664
2bgm NAJSecoisolariciresinol dehydrogenase 1.1.1.331 0.663
2cvq NDPMalate dehydrogenase / 0.663
3a4v NADNDP-sugar epimerase / 0.663
1hku NADC-terminal-binding protein 1 1.1.1 0.662
1i3l NADUDP-glucose 4-epimerase / 0.660
3wsw NADL-lactate dehydrogenase / 0.660
1ur5 NADMalate dehydrogenase / 0.659
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.658
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.658
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.656
4k28 NADShikimate dehydrogenase family protein / 0.656
1nai NADUDP-glucose 4-epimerase 5.1.3.2 0.655
1up7 NAD6-phospho-beta-glucosidase BglT 3.2.1.86 0.655
3ru9 NADUDP-N-acetylglucosamine 4-epimerase / 0.655
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.655
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.654
3cif NADGlyceraldehyde-3-phosphate dehydrogenase / 0.654
3icp NADNAD-dependent epimerase/dehydratase / 0.653
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.653
2dc1 NADProbable L-aspartate dehydrogenase / 0.652
2p9c NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.652
2p9e NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.651
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.651
4cpd NADAlcohol dehydrogenase / 0.651
3pgx NADUncharacterized NAD-dependent oxidoreductase MAP_4146 / 0.650
4nbw NADShort-chain dehydrogenase/reductase SDR / 0.650