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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1z48 FMN NADPH dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1z48 FMNNADPH dehydrogenase / 1.317
3hf3 FMNChromate reductase / 1.234
1z44 FMNNADPH dehydrogenase / 1.211
1z41 FMNNADPH dehydrogenase / 1.179
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 1.167
3gr8 FMNNADPH dehydrogenase / 1.124
2gou FMNNADH:flavin oxidoreductase Sye1 / 1.065
2gqa FMNNADH:flavin oxidoreductase Sye1 / 1.062
3n14 FMNXenobiotic reductase / 1.034
4uth FMNXenobiotic reductase / 1.029
2h8x FMNXenA / 1.012
5cpm FNRNADH:flavin oxidoreductase / 1.003
4utk FNRXenobiotic reductase / 1.001
3l5l FMNXenobiotic reductase / 0.987
4utm FNRXenobiotic reductase / 0.972
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.937
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.936
1gwj FMNMorphinone reductase / 0.922
4utl FNRXenobiotic reductase / 0.922
4qnw FMNChanoclavine-I aldehyde reductase easA / 0.921
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 0.917
3l67 FMNXenobiotic reductase / 0.917
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.914
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 0.909
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 0.908
4yco FMNtRNA-dihydrouridine(16) synthase / 0.905
1h51 FMNPentaerythritol tetranitrate reductase / 0.902
1h63 FMNPentaerythritol tetranitrate reductase / 0.893
1oya FMNNADPH dehydrogenase 1 1.6.99.1 0.890
3p84 FMNPentaerythritol tetranitrate reductase / 0.889
4tmc FMNOld yellow enzyme / 0.889
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 0.887
1vhn FMNtRNA-dihydrouridine synthase / 0.879
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 0.874
3tjl FMNNADPH dehydrogenase / 0.873
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.873
2bsl FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.866
3p8j FMNPentaerythritol tetranitrate reductase / 0.865
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.864
1vyr FMNPentaerythritol tetranitrate reductase / 0.864
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.864
4aws FMNNADH:flavin oxidoreductase Sye1 / 0.860
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 0.860
3f03 FMNPentaerythritol tetranitrate reductase / 0.859
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 0.857
4tmb FMNOld yellow enzyme / 0.857
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.856
3p67 FMNPentaerythritol tetranitrate reductase / 0.854
1h50 FMNPentaerythritol tetranitrate reductase / 0.853
3atz FMNProstaglandin F2a synthase / 0.852
2abb FMNPentaerythritol tetranitrate reductase / 0.850
3p8i FMNPentaerythritol tetranitrate reductase / 0.850
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 0.848
4e2d FMNDehydrogenase / 0.847
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 0.842
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.838
2djl FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.837
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.836
3gka FMNN-ethylmaleimide reductase / 0.834
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.830
2djx FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.829
4df2 FMNNADPH dehydrogenase / 0.829
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.828
3p62 FMNPentaerythritol tetranitrate reductase / 0.821
4qai FMNNADPH dehydrogenase / 0.819
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.816
4e2b FMNDehydrogenase / 0.812
4xq6 FMNDihydroorotate dehydrogenase (quinone) / 0.797
4yl2 FMNLactate oxidase / 0.794
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 0.793
1h7w FMNDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.790
2zfa FMNLactate oxidase / 0.788
2z6i FMN2-nitropropane dioxygenase / 0.787
2du2 FMNLactate oxidase / 0.780
3vkj FNRIsopentenyl-diphosphate delta-isomerase / 0.779
3p74 FMNPentaerythritol tetranitrate reductase / 0.776
1ofd FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.774
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.772
1dor FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.771
1lm1 FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.767
1ep3 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.766
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.765
3n19 FNRXenobiotic reductase / 0.765
2nli FMNLactate oxidase / 0.763
2j6x FMNLactate oxidase / 0.760
4cw5 FMNDfnA / 0.759
4m5p FMNNADPH dehydrogenase / 0.758
1vcf FMNIsopentenyl-diphosphate delta-isomerase / 0.756
4yx6 FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.752
2zry FNRIsopentenyl-diphosphate delta-isomerase / 0.751
4iql FMNEnoyl-(Acyl-carrier-protein) reductase II / 0.750
1kbi FMNCytochrome b2, mitochondrial 1.1.2.3 0.749
2zrv FNRIsopentenyl-diphosphate delta-isomerase / 0.749
3giy FMN(S)-mandelate dehydrogenase 1.1.99.31 0.748
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.746
3oix FMNDihydroorotate dehydrogenase / 0.739
4jic FMNGTN Reductase / 0.739
3p82 FMNPentaerythritol tetranitrate reductase / 0.737
3b04 OOPIsopentenyl-diphosphate delta-isomerase / 0.736
1gox FMNPeroxisomal (S)-2-hydroxy-acid oxidase 1.1.3.15 0.732
3b05 FNRIsopentenyl-diphosphate delta-isomerase / 0.732
1llw FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.728
4rje FNRLactate oxidase / 0.720
1ofe FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.717
1k02 FMNNADPH dehydrogenase 1 1.6.99.1 0.716
2gjn FMNNitronate monooxygenase 1.13.12.16 0.715
2zrz FNRIsopentenyl-diphosphate delta-isomerase / 0.713
1szf FMNCytochrome b2, mitochondrial 1.1.2.3 0.708
2gjl FMNNitronate monooxygenase 1.13.12.16 0.707
4z38 FMNMlnA / 0.700
3fst FAD5,10-methylenetetrahydrofolate reductase 1.5.1.20 0.698
1dxq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.692
1ea0 FMNGlutamate synthase [NADPH] large chain 1.4.1.13 0.692
1kbj FMNCytochrome b2, mitochondrial 1.1.2.3 0.692
4z9r FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.692
4qof FMNRibosyldihydronicotinamide dehydrogenase [quinone] / 0.690
4m0c FMNFMN-dependent NADH-azoreductase 1 / 0.689
2zrx FMNIsopentenyl-diphosphate delta-isomerase / 0.688
2reh FADNitroalkane oxidase 1.7.3.1 0.676
5ebu FMNLactate oxidase / 0.676
1djq FMNTrimethylamine dehydrogenase 1.5.8.2 0.673
3fsu FAD5,10-methylenetetrahydrofolate reductase 1.5.1.20 0.673
2q3o FMN12-oxophytodienoate reductase 3 1.3.1.42 0.672
2ohj FMNType A flavoprotein FprA 1 0.671
2z9d FMNFMN-dependent NADH-azoreductase / 0.670
4wzh FMNDihydroorotate dehydrogenase (fumarate) / 0.669
1uum FMNDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.667
2eba FADPutative glutaryl-CoA dehydrogenase / 0.667
3c3n FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.663
3w8w FADPutative FAD-dependent oxygenase EncM / 0.663
4ef8 FMNDihydroorotate dehydrogenase (fumarate) / 0.663
1zwl FMNNAD(P)H dehydrogenase (quinone) 1.6.5.2 0.662
1iqr FADDeoxyribodipyrimidine photo-lyase 4.1.99.3 0.661
4ef9 FMNDihydroorotate dehydrogenase (fumarate) / 0.661
4kuk RBFPutative blue-light photoreceptor / 0.659
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.657
2vxa RBFDodecin / 0.657
2iid FADL-amino-acid oxidase 1.4.3.2 0.656
1llz FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.655
2j07 FADDeoxyribodipyrimidine photo-lyase 4.1.99.3 0.655
3n39 FMNProtein NrdI / 0.655
4gu5 FADCryptochrome-1 / 0.653
1ych FMNNitric oxide reductase 1 0.652
3nf4 FADAcyl-CoA dehydrogenase domain-containing protein / 0.652
3bw3 FMNPutative 2-nitropropane dioxygenase / 0.651
4i6g FADCryptochrome-2 / 0.651
1dxo FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.650
1ofv FMNFlavodoxin / 0.650