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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1yvj 4ST Tyrosine-protein kinase JAK3 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 1.059
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.895
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.858
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.801
4yzc STUSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.798
1xjd STUProtein kinase C theta type 2.7.11.13 0.793
4kik KSAInhibitor of nuclear factor kappa-B kinase subunit beta 2.7.11.10 0.769
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.767
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.764
3bkb STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.758
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
1byg STUTyrosine-protein kinase CSK / 0.740
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.734
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 0.725
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.720
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.719
3cbl STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.719
2j0k 4STFocal adhesion kinase 1 2.7.10.2 0.716
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.715
2buj STUSerine/threonine-protein kinase 16 / 0.705
4erw STUCyclin-dependent kinase 2 2.7.11.22 0.702
3a4o STUTyrosine-protein kinase Lyn 2.7.10.2 0.700
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.699
1nvs UCMSerine/threonine-protein kinase Chk1 2.7.11.1 0.696
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.689
3a60 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.687
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.686
2hy8 1STSerine/threonine-protein kinase PAK 1 2.7.11.1 0.682
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.682
3l8p 0CEAngiopoietin-1 receptor 2.7.10.1 0.682
4gh2 HK0Serine/threonine-protein kinase Chk1 2.7.11.1 0.668
5e8x STUTGF-beta receptor type-1 2.7.11.30 0.668
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.667
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.667
2erz HFScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.664
1nxk STUMAP kinase-activated protein kinase 2 2.7.11.1 0.662
4ftt 6HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.661
4e5f 0N7Polymerase acidic protein / 0.660
2r0u M54Serine/threonine-protein kinase Chk1 2.7.11.1 0.659
4ftr 5HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.658
3l9l L9LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
3zew STUEphrin type-B receptor 4 2.7.10.1 0.655
4bid IE8Mitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.655
3tku M77Serine/threonine-protein kinase MRCK beta 2.7.11.1 0.654
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.653
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.652
4ftu 7HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.652