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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1xjd STU Protein kinase C theta type 2.7.11.13

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1xjd STUProtein kinase C theta type 2.7.11.13 1.105
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.903
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.874
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 0.859
3a62 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.858
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.848
3a60 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.840
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.793
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.775
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.768
1nxk STUMAP kinase-activated protein kinase 2 2.7.11.1 0.766
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.765
4kik KSAInhibitor of nuclear factor kappa-B kinase subunit beta 2.7.11.10 0.763
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.754
2hy8 1STSerine/threonine-protein kinase PAK 1 2.7.11.1 0.749
1byg STUTyrosine-protein kinase CSK / 0.746
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3zew STUEphrin type-B receptor 4 2.7.10.1 0.741
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.740
1yhs STUSerine/threonine-protein kinase pim-1 2.7.11.1 0.733
1nvs UCMSerine/threonine-protein kinase Chk1 2.7.11.1 0.730
1oky STU3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.722
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.702
4c58 824Cyclin-G-associated kinase 2.7.11.1 0.702
4wsq KSAAP2-associated protein kinase 1 2.7.11.1 0.698
3a4o STUTyrosine-protein kinase Lyn 2.7.10.2 0.696
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.695
3cbl STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.695
4yzc STUSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.695
1snu STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.689
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.686
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.686
4ftt 6HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.686
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.679
4mvf STUCalcium-dependent protein kinase 2 2.7.11.1 0.678
4hvh 19RTyrosine-protein kinase JAK3 2.7.10.2 0.677
4fr4 STUSerine/threonine-protein kinase 32A 2.7.11.1 0.675
4ft0 HK9Serine/threonine-protein kinase Chk1 2.7.11.1 0.674
1stc STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
2wti WTISerine/threonine-protein kinase Chk2 2.7.11.1 0.659
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.657
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.654
3v3v MYUMitogen-activated protein kinase 8 2.7.11.24 0.653
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.652
2b7a IZATyrosine-protein kinase JAK2 / 0.651