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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1t74 DHT Androgen receptor

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1t74 DHTAndrogen receptor / 1.174
2pio DHTAndrogen receptor / 1.167
2pip DHTAndrogen receptor / 1.164
1t73 DHTAndrogen receptor / 1.154
2piu DHTAndrogen receptor / 1.141
2pit DHTAndrogen receptor / 1.136
1t5z DHTAndrogen receptor / 1.130
2ama DHTAndrogen receptor / 1.130
4oea DHTAndrogen receptor / 1.123
1t7r DHTAndrogen receptor / 1.118
1t79 DHTAndrogen receptor / 1.117
4oez DHTAndrogen receptor / 1.117
4oey DHTAndrogen receptor / 1.112
1t65 DHTAndrogen receptor / 1.095
1t76 DHTAndrogen receptor / 1.092
2piw DHTAndrogen receptor / 1.084
4ofr DHTAndrogen receptor / 1.079
1t7f DHTAndrogen receptor / 1.077
2pkl DHTAndrogen receptor / 1.077
2pix DHTAndrogen receptor / 1.075
2piq DHTAndrogen receptor / 1.073
1t7m DHTAndrogen receptor / 1.024
2z4j DHTAndrogen receptor / 1.023
2ylp TESAndrogen receptor / 1.014
2q7i TESAndrogen receptor / 1.000
2q7k TESAndrogen receptor / 0.989
1xj7 DHTAndrogen receptor / 0.986
2q7l TESAndrogen receptor / 0.948
4hlw TESAndrogen receptor / 0.948
4oed DHTAndrogen receptor / 0.947
2pnu ENMAndrogen receptor / 0.931
1t7t DHTAndrogen receptor / 0.875
1t63 DHTAndrogen receptor / 0.867
2piv DHTAndrogen receptor / 0.866
2ao6 R18Androgen receptor / 0.864
1xow R18Androgen receptor / 0.811
1xq3 R18Androgen receptor / 0.800
4ofu DHTAndrogen receptor / 0.798
1gs4 ZK5Androgen receptor / 0.795
2pir DHTAndrogen receptor / 0.783
4e5l DBHPolymerase acidic protein / 0.767
2am9 TESAndrogen receptor / 0.754
2amb 17HAndrogen receptor / 0.753
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2ylq TESAndrogen receptor / 0.738
1qyw 5SDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.705
1lri CLRBeta-elicitin cryptogein / 0.701
2qpy DHTAndrogen receptor / 0.697
2ylo TESAndrogen receptor / 0.694
3uzx AOM3-oxo-5-beta-steroid 4-dehydrogenase / 0.693
1xu7 CPSCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.689
4k7a DHTAndrogen receptor / 0.689
1lhn AONSex hormone-binding globulin / 0.688
3uzx AOX3-oxo-5-beta-steroid 4-dehydrogenase / 0.685
2d09 FLVBiflaviolin synthase CYP158A2 / 0.682
3nhx ASDSteroid Delta-isomerase 5.3.3.1 0.682
3uzz ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.681
1g50 ESTEstrogen receptor / 0.679
4qe6 JN3Bile acid receptor / 0.679
2q7j TESAndrogen receptor / 0.676
2j7x ESTEstrogen receptor beta / 0.674
4q0a 4OAVitamin D3 receptor A / 0.674
1lho AOMSex hormone-binding globulin / 0.672
1jtv TESEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.667
3iw1 ASDSteroid C26-monooxygenase 1.14.13.141 0.665
1osv CHCBile acid receptor / 0.663
3f3y 4OABile salt sulfotransferase 2.8.2.14 0.659
3w5t LHPVitamin D3 receptor / 0.652
1yhs STUSerine/threonine-protein kinase pim-1 2.7.11.1 0.651
4a32 MYAGlycylpeptide N-tetradecanoyltransferase / 0.651
1irj CPSProtein S100-A9 / 0.650