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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1t44 ATP Actin, alpha skeletal muscle

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1t44 ATPActin, alpha skeletal muscle / 1.201
1qz5 ATPActin, alpha skeletal muscle / 1.173
1s22 ATPActin, alpha skeletal muscle / 1.141
4k41 ATPActin, alpha skeletal muscle / 1.127
4pkg ATPActin, alpha skeletal muscle / 1.110
1c0f ATPMajor actin / 1.101
1wua ATPActin, alpha skeletal muscle / 1.096
4b1v ATPActin, alpha skeletal muscle / 1.096
4pki ATPActin, alpha skeletal muscle / 1.078
4pl8 ATPActin, alpha skeletal muscle / 1.074
1dej ATPMajor actin / 1.073
2q36 ATPActin, alpha skeletal muscle / 1.072
2v51 ATPActin, alpha skeletal muscle / 1.069
3a5o ATPMajor actin / 1.055
3m1f ATPActin, alpha skeletal muscle / 1.048
3m6g ATPActin, alpha skeletal muscle / 1.047
3ffk ATPActin, alpha skeletal muscle / 1.038
1eqy ATPActin, alpha skeletal muscle / 1.020
1kxp ATPActin, alpha skeletal muscle / 1.019
2q97 ATPActin, alpha skeletal muscle / 1.017
3mn9 ATPActin-5C / 1.016
5ce3 ATPActin / 1.015
4cbx ATPActin-2 / 1.002
3chw ATPMajor actin / 0.999
3eks ATPActin-5C / 0.999
1mdu ATPActin, alpha skeletal muscle / 0.998
3tu5 ATPActin, alpha skeletal muscle / 0.997
1nlv ATPMajor actin / 0.995
2a41 ATPActin, alpha skeletal muscle / 0.992
3w3d ATPActin, gamma-enteric smooth muscle / 0.989
3eku ATPActin-5C / 0.984
3mn6 ATPActin-5C / 0.983
1rgi ATPActin, alpha skeletal muscle / 0.956
3mn7 ATPActin-5C / 0.952
1atn ATPActin, alpha skeletal muscle / 0.950
4ci6 ATPActin / 0.949
2oan ATPActin, cytoplasmic 1 / 0.943
3wt0 ATPCell division protein FtsA / 0.937
3daw ATPActin, alpha skeletal muscle / 0.931
2p9k ATPActin-related protein 2 / 0.927
1lot ATPActin, alpha skeletal muscle / 0.905
4pkh ADPActin, alpha skeletal muscle / 0.904
4b9q ATPChaperone protein DnaK / 0.898
3el2 ATPActin-5C / 0.895
4m63 ATPActin-5C / 0.869
3a5m ATPMajor actin / 0.862
1ijj ATPActin, alpha skeletal muscle / 0.845
1yxq ATPActin, alpha skeletal muscle / 0.835
1h1v ATPActin, alpha skeletal muscle / 0.819
4eht ADP2-hydroxyisocaproyl-CoA dehydratase activator / 0.805
4ehu ANP2-hydroxyisocaproyl-CoA dehydratase activator / 0.799
1rfq ATPActin, alpha skeletal muscle / 0.798
1nm1 ATPMajor actin / 0.791
2e2q ADPATP-dependent hexokinase / 0.786
4a62 ANPPlasmid segregation protein ParM / 0.766
1nmd ATPMajor actin / 0.765
3ule ATPActin-related protein 2 / 0.761
2d0o ADPDiol dehydratase-reactivating factor alpha subunit / 0.757
4k42 ADPActin, alpha skeletal muscle / 0.751
4jhd ANPActin-5C / 0.745
3wqt ANPCell division protein FtsA / 0.736
4brg GNPEctonucleoside triphosphate diphosphohydrolase I / 0.734
4brd ANPEctonucleoside triphosphate diphosphohydrolase I / 0.729
4bri UNPEctonucleoside triphosphate diphosphohydrolase I / 0.709
2zgz GNPPlasmid segregation protein ParM / 0.697
4a61 ANPPlasmid segregation protein ParM / 0.694
1mwm ADPPlasmid segregation protein ParM / 0.689
5f1x ATP78 kDa glucose-regulated protein / 0.688
4nke RISFarnesyl pyrophosphate synthase 2.5.1.10 0.687
3ldl ATP78 kDa glucose-regulated protein / 0.685
3u4l ATPActin, cytoplasmic 1 / 0.679
2pz8 APCNH(3)-dependent NAD(+) synthetase / 0.678
2qwn ADPHeat shock cognate 71 kDa protein / 0.674
3u9d ATPActin, alpha skeletal muscle / 0.674
3ldo ANP78 kDa glucose-regulated protein / 0.672
4xjc TTPdCTP deaminase / 0.671
2a84 ATPPantothenate synthetase 6.3.2.1 0.670
4k43 ADPActin, alpha skeletal muscle / 0.669
4xjx ATPType I restriction enzyme EcoR124II R protein 3.1.21.3 0.669
1ngd ADPHeat shock cognate 71 kDa protein / 0.668
3ryh GTPTubulin alpha chain / 0.668
1yv5 RISFarnesyl pyrophosphate synthase 2.5.1.10 0.666
4dwb 0M7Farnesyl pyrophosphate synthase / 0.661
3wqu ATPCell division protein FtsA / 0.660
2x60 GTPMannose-1-phosphate guanylyltransferase / 0.655
1sxj ADPReplication factor C subunit 5 / 0.654
2jib ADPOxalyl-CoA decarboxylase 4.1.1.8 0.654
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
4yj2 GTPTubulin alpha-1B chain / 0.654
2zgy GDPPlasmid segregation protein ParM / 0.652
4to0 DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.652
4ymv ATPABC-type polar amino acid transport system, ATPase component / 0.652
4gvz ADPArginine kinase 2.7.3.3 0.651
5itz GTPTubulin alpha-1B chain / 0.651
1rqj RISFarnesyl diphosphate synthase 2.5.1.10 0.650
2g28 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.650
5bsm ATP4-coumarate--CoA ligase 2 6.2.1.12 0.650