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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1t40 ID5 Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1t40 ID5Aldose reductase 1.1.1.21 1.265
3g5e Q74Aldose reductase 1.1.1.21 0.914
3len ZSTAldose reductase 1.1.1.21 0.879
2pdf ZSTAldose reductase 1.1.1.21 0.839
4gca 2X9Aldose reductase 1.1.1.21 0.839
3ght LDTAldose reductase 1.1.1.21 0.818
2pdc 393Aldose reductase 1.1.1.21 0.794
3mb9 ZSTAldose reductase 1.1.1.21 0.791
2pdb ZSTAldose reductase 1.1.1.21 0.782
2duz ZSTAldose reductase 1.1.1.21 0.781
2pdm ZSTAldose reductase 1.1.1.21 0.777
3t42 3T4Aldose reductase 1.1.1.21 0.775
3ghu LDTAldose reductase 1.1.1.21 0.773
1z3n 3NAAldose reductase 1.1.1.21 0.765
2ikj 393Aldose reductase 1.1.1.21 0.764
2pdn 47DAldose reductase 1.1.1.21 0.760
2pzn 393Aldose reductase 1.1.1.21 0.760
1t41 ID5Aldose reductase 1.1.1.21 0.759
2hvn ZSTAldose reductase 1.1.1.21 0.759
2fz8 ZSTAldose reductase 1.1.1.21 0.757
2pdp 393Aldose reductase 1.1.1.21 0.750
3m64 393Aldose reductase 1.1.1.21 0.747
3m4h 388Aldose reductase 1.1.1.21 0.744
2fz9 ZSTAldose reductase 1.1.1.21 0.737
3mc5 393Aldose reductase 1.1.1.21 0.737
2hv5 ZSTAldose reductase 1.1.1.21 0.735
3ghr LDTAldose reductase 1.1.1.21 0.731
3ghs LDTAldose reductase 1.1.1.21 0.731
2pdj 393Aldose reductase 1.1.1.21 0.730
1us0 LDTAldose reductase 1.1.1.21 0.729
2i16 LDTAldose reductase 1.1.1.21 0.729
2qxw LDTAldose reductase 1.1.1.21 0.716
2i17 LDTAldose reductase 1.1.1.21 0.715
2pdx ZSTAldose reductase 1.1.1.21 0.708
2pdh 47DAldose reductase 1.1.1.21 0.706
2dux ZSTAldose reductase 1.1.1.21 0.704
2nvc ITAAldose reductase 1.1.1.21 0.703
2pdu 393Aldose reductase 1.1.1.21 0.698
2pdq 47DAldose reductase 1.1.1.21 0.695
4yu1 53NAldose reductase 1.1.1.21 0.693
1frb ZSTAldose reductase-related protein 2 / 0.677
2hvo ZSTAldose reductase 1.1.1.21 0.676
2pdg 47DAldose reductase 1.1.1.21 0.667