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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1rzy 5AS Histidine triad nucleotide-binding protein 1 3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1rzy 5ASHistidine triad nucleotide-binding protein 1 3 0.977
4eqe KAAHistidine triad nucleotide-binding protein 1 3 0.880
4eqg A5AHistidine triad nucleotide-binding protein 1 3 0.859
3n1s 5GPPurine nucleoside phosphoramidase / 0.848
3qgz ADNHistidine triad nucleotide-binding protein 1 3 0.769
5i2f BS5Histidine triad nucleotide-binding protein 1 3 0.754
4egu 5GPPutative histidine triad (HIT) protein / 0.745
3oxk 5GPHistidine triad nucleotide-binding protein 3 0.698
1st0 GTGm7GpppX diphosphatase 3.6.1.59 0.678
1xmm M7Gm7GpppX diphosphatase 3.6.1.59 0.677
1z3c SA8mRNA cap guanine-N7 methyltransferase 2.1.1.56 0.675
2q28 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.674
2h39 ADQADP-glucose phosphorylase / 0.670
4ckc SAHmRNA-capping enzyme catalytic subunit 2.1.1.56 0.666
4i5v B4PDiadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 2 / 0.666
3n1t 5GPPurine nucleoside phosphoramidase / 0.659
4iv8 SAMPhosphoethanolamine N-methyltransferase,putative / 0.658
1y8q ATPSUMO-activating enzyme subunit 2 6.3.2 0.654
4ckb SAHmRNA-capping enzyme catalytic subunit 2.1.1.56 0.654
3bgi SAHThiopurine S-methyltransferase 2.1.1.67 0.653
5fit AP2Bis(5'-adenosyl)-triphosphatase 3.6.1.29 0.650