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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1qyx ASD Estradiol 17-beta-dehydrogenase 1 1.1.1.62

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1qyx ASDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.973
1qyw 5SDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.857
3dey DHTEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.820
3klm DHTEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.820
1efz PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.744
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1v2h GUNPurine nucleoside phosphorylase 2.4.2.1 0.744
2puc GUNHTH-type transcriptional repressor PurR / 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4ek9 EP4Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.744
1jtv TESEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.743
4at2 ASDPossible succinate dehydrogenase / 0.703
3cot STR3-oxo-5-beta-steroid 4-dehydrogenase / 0.695
1lhu ESTSex hormone-binding globulin / 0.693
4pxm ESTEstrogen receptor / 0.690
3eqm ASDAromatase 1.14.14.14 0.689
4jbt ASDCytochrome P450 monooxygenase / 0.689
3vhu SNLMineralocorticoid receptor / 0.687
1gwr ESTEstrogen receptor / 0.684
2ab2 SNLMineralocorticoid receptor / 0.683
5dxg ESTEstrogen receptor / 0.683
1kdm DHTSex hormone-binding globulin / 0.681
2ylp TESAndrogen receptor / 0.678
4ofr DHTAndrogen receptor / 0.678
3w1w CHDFerrochelatase, mitochondrial 4.99.1.1 0.668
2cbo TH2Neocarzinostatin / 0.667
1yb1 AOIEstradiol 17-beta-dehydrogenase 11 1.1.1.62 0.666
4klr CHDFerrochelatase, mitochondrial 4.99.1.1 0.666
4q0a 4OAVitamin D3 receptor A / 0.666
2rlc CHDCholoylglycine hydrolase 3.5.1.24 0.665
4hlw TESAndrogen receptor / 0.665
3w5p 4OAVitamin D3 receptor / 0.664
3w5q 3KLVitamin D3 receptor / 0.664
2ylo TESAndrogen receptor / 0.663
3iw1 ASDSteroid C26-monooxygenase 1.14.13.141 0.663
1ozq PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1p0e PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1ulb GUNPurine nucleoside phosphorylase 2.4.2.1 0.660
2aa5 STRMineralocorticoid receptor / 0.660
2pot GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2pwu GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2z1x PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3bld PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4hqv QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hvx QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1zhy CLROxysterol-binding protein homolog 4 / 0.654
2pip DHTAndrogen receptor / 0.651
2aa7 1CAMineralocorticoid receptor / 0.650