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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1qsr ACO HAT A1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1qsr ACOHAT A1 / 1.174
5h84 1VUHistone acetyltransferase KAT2A 2.3.1.48 0.959
5h86 BCOHistone acetyltransferase KAT2A 2.3.1.48 0.938
1pua COAHAT A1 / 0.912
1z4r ACOHistone acetyltransferase KAT2A 2.3.1.48 0.902
1pu9 COAHAT A1 / 0.893
1qsn COAHAT A1 / 0.877
1kuv CA5Serotonin N-acetyltransferase / 0.836
1m1d LYXHAT A1 / 0.822
3to6 LYS_CMCHistone acetyltransferase ESA1 / 0.821
1mja COAHistone acetyltransferase ESA1 / 0.819
5kgp ACOPredicted acetyltransferase / 0.814
2ozu ACOHistone acetyltransferase KAT6A / 0.807
2ou2 ACOHistone acetyltransferase KAT5 / 0.798
5kgh ACOPredicted acetyltransferase / 0.796
5kf8 ACOPredicted acetyltransferase / 0.794
5kf2 ACOPredicted acetyltransferase / 0.792
1kux CA3Serotonin N-acetyltransferase / 0.785
5kf9 ACOPredicted acetyltransferase / 0.781
5kf1 ACOPredicted acetyltransferase / 0.778
1mj9 COAHistone acetyltransferase ESA1 / 0.772
5kgj ACOPredicted acetyltransferase / 0.771
1mjb ACOHistone acetyltransferase ESA1 / 0.768
2q4v ACODiamine acetyltransferase 2 2.3.1.57 0.768
1fy7 COAHistone acetyltransferase ESA1 / 0.767
2y0m ACOHistone acetyltransferase KAT8 / 0.764
3vwe COAAlpha-tubulin N-acetyltransferase 1 / 0.764
2zpa ACOtRNA(Met) cytidine acetyltransferase TmcA / 0.760
4qvt ACOAcetyltransferase YpeA 2.3.1 0.760
2cns ACORibosomal-protein-alanine acetyltransferase / 0.752
1wwz ACOUncharacterized protein / 0.742
2vzz SCAPutative succinyl-CoA transferase Rv0802c 2.8.3 0.740
4u9z COAAlpha-tubulin N-acetyltransferase 1 / 0.738
3r1k COAN-acetyltransferase Eis / 0.733
4b5o ACOAlpha-tubulin N-acetyltransferase 1 / 0.733
1qsm ACOHistone acetyltransferase HPA2 / 0.724
4lx9 ACON-alpha-acetyltransferase 2.3.1 0.723
1cm0 COAHistone acetyltransferase KAT2B 2.3.1.48 0.721
2rc4 ACOHistone acetyltransferase KAT6A / 0.721
2bsw CAOProbable acetyltransferase / 0.718
2vxk COAGlucosamine 6-phosphate acetyltransferase, putative / 0.718
5kf2 COAPredicted acetyltransferase / 0.717
2jdc CAOProbable acetyltransferase / 0.714
4kvx ACON-terminal acetyltransferase A complex catalytic subunit ard1 2.3.1.88 0.713
2jdd ACOProbable acetyltransferase / 0.712
2r8v ACOAmino-acid acetyltransferase / 0.710
2vez ACOGlucosamine 6-phosphate acetyltransferase, putative / 0.710
2fxf ACODiamine acetyltransferase 1 / 0.706
4r3k COAN-alpha-acetyltransferase 2.3.1 0.706
1ib1 COTSerotonin N-acetyltransferase / 0.705
1tiq COASpermidine/spermine N(1)-acetyltransferase / 0.705
3r95 ACOMccE protein / 0.703
4ag7 COAGlucosamine 6-phosphate N-acetyltransferase / 0.703
2bei ACODiamine acetyltransferase 2 2.3.1.57 0.701
2x7b COAN-alpha-acetyltransferase 2.3.1 0.701
5c88 COAN-alpha-acetyltransferase / 0.701
4xpd ACON-terminal acetyltransferase A complex subunit NAT5 2.3.1 0.699
1s7n COAAcetyl transferase / 0.698
1cjw COTSerotonin N-acetyltransferase / 0.697
3gya COAGCN5-related N-acetyltransferase / 0.696
1i12 ACOGlucosamine 6-phosphate N-acetyltransferase / 0.695
1p0h ACOMycothiol acetyltransferase 2.3.1.189 0.691
2vqy ACOAAC(6')-Ib / 0.691
2ge3 ACOProbable acetyltransferase / 0.690
1b87 ACOAac(6')-Ii protein / 0.688
2c27 ACOMycothiol acetyltransferase 2.3.1.189 0.688
1n71 COAAac(6')-Ii protein / 0.687
2prb COAAminoglycoside 6-N-acetyltransferase type Ib11 / 0.686
3exn ACOProbable acetyltransferase / 0.686
5kf8 COAPredicted acetyltransferase / 0.686
2fiw ACOGCN5-related N-acetyltransferase:Aminotransferase, class-II / 0.685
3te4 ACODopamine N-acetyltransferase / 0.684
1j4j ACOAcetyltransferase 2.3.1 0.683
1s5k COAAminoglycoside N(6')-acetyltransferase type 1 / 0.682
4cry ACOPanD regulatory factor / 0.682
4ri1 ACOUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase 2.3.1.202 0.679
3cz7 ACOHistone acetyltransferase RTT109 2.3.1.48 0.677
3mgd ACOPredicted acetyltransferase / 0.677
2ft0 ACOdTDP-fucosamine acetyltransferase / 0.676
2giv ACOHistone acetyltransferase KAT8 / 0.676
1bo4 COAAminoglycoside-(3)-N-acetyltransferase / 0.673
2zfn ACOHistone acetyltransferase RTT109 2.3.1.48 0.673
4ua3 COAN-alpha-acetyltransferase 40 2.3.1 0.673
1ghe ACOAcetyltransferase 2.3.1 0.671
3r96 ACOMccE protein / 0.670
3pgp ACOUncharacterized protein / 0.668
4mxe ACON-acetyltransferase ESCO1 2.3.1 0.667
1l0c COTSerotonin N-acetyltransferase / 0.664
3s6f COAUncharacterized protein / 0.663
4kub COAUncharacterized protein / 0.660
4zm6 ACON-acetyl-beta-D glucosaminidase / 0.659
4hkf ACOAlpha-tubulin N-acetyltransferase 1 / 0.658
4ag9 COAGlucosamine 6-phosphate N-acetyltransferase / 0.654
4xnh ACON-terminal acetyltransferase A complex subunit NAT5 2.3.1 0.653
4ava ACOAcetyltransferase Pat 2.3.1 0.652