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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1q3d STU Glycogen synthase kinase-3 beta 2.7.11.26

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1q3d STUGlycogen synthase kinase-3 beta 2.7.11.26 0.951
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.833
3ckx STUSerine/threonine-protein kinase 24 2.7.11.1 0.788
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.783
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.782
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.778
4qmy STUSerine/threonine-protein kinase 24 2.7.11.1 0.772
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.771
2hy8 1STSerine/threonine-protein kinase PAK 1 2.7.11.1 0.770
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.752
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4mvf STUCalcium-dependent protein kinase 2 2.7.11.1 0.742
4fr4 STUSerine/threonine-protein kinase 32A 2.7.11.1 0.741
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.738
5e8x STUTGF-beta receptor type-1 2.7.11.30 0.738
4u9a STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.735
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.732
3bkb STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.730
1stc STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.713
2in6 839Wee1-like protein kinase 2.7.10.2 0.712
2z2w 770Wee1-like protein kinase 2.7.10.2 0.708
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.707
2io6 330Wee1-like protein kinase 2.7.10.2 0.707
3biz 61EWee1-like protein kinase 2.7.10.2 0.704
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.703
3bi6 396Wee1-like protein kinase 2.7.10.2 0.694
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.690
1nvs UCMSerine/threonine-protein kinase Chk1 2.7.11.1 0.675
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.672
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.668
4erw STUCyclin-dependent kinase 2 2.7.11.22 0.664
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.663
4e5f 0N7Polymerase acidic protein / 0.660
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.657
3d7t STUTyrosine-protein kinase CSK / 0.657
3f69 XDRSerine/threonine-protein kinase PknB 2.7.11.1 0.656
2r0u M54Serine/threonine-protein kinase Chk1 2.7.11.1 0.654
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 0.653
1uu9 BI33-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.650