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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1pxp CK8 Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1pxp CK8Cyclin-dependent kinase 2 2.7.11.22 0.924
1pxm CK5Cyclin-dependent kinase 2 2.7.11.22 0.840
3sw7 19KCyclin-dependent kinase 2 2.7.11.22 0.778
1pxl CK4Cyclin-dependent kinase 2 2.7.11.22 0.777
4fko 20KCyclin-dependent kinase 2 2.7.11.22 0.767
3sw4 18KCyclin-dependent kinase 2 2.7.11.22 0.747
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2w06 FRVCyclin-dependent kinase 2 2.7.11.22 0.704
4ek8 16KCyclin-dependent kinase 2 2.7.11.22 0.695
1urw I1PCyclin-dependent kinase 2 2.7.11.22 0.692
2c5n CK8Cyclin-dependent kinase 2 2.7.11.22 0.690
3tiz 3TICyclin-dependent kinase 2 2.7.11.22 0.686
1pxk CK3Cyclin-dependent kinase 2 2.7.11.22 0.680
1oir HDYCyclin-dependent kinase 2 2.7.11.22 0.679
1pxo CK7Cyclin-dependent kinase 2 2.7.11.22 0.678
4fkg 4CKCyclin-dependent kinase 2 2.7.11.22 0.675
2xnb Y8LCyclin-dependent kinase 2 2.7.11.22 0.674
3igg EFQCyclin-dependent kinase 2 2.7.11.22 0.672
4b6l 9ZPSerine/threonine-protein kinase PLK3 2.7.11.21 0.672
1oiq HDUCyclin-dependent kinase 2 2.7.11.22 0.671
3nux 3NVCyclin-dependent kinase 6 2.7.11.22 0.670
1vyz N5BCyclin-dependent kinase 2 2.7.11.22 0.668
1gih 1PUCyclin-dependent kinase 2 2.7.11.22 0.666
4bcm T7ZCyclin-dependent kinase 2 2.7.11.22 0.665
2wxv WXVCyclin-dependent kinase 2 2.7.11.22 0.661
4e5f 0N7Polymerase acidic protein / 0.660
2xmy CDKCyclin-dependent kinase 2 2.7.11.22 0.659
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.656
2b52 D42Cyclin-dependent kinase 2 2.7.11.22 0.654
3uli 1N3Cyclin-dependent kinase 2 2.7.11.22 0.652
3h3c P1EProtein-tyrosine kinase 2-beta 2.7.10.2 0.651
3lfq A28Cyclin-dependent kinase 2 2.7.11.22 0.651
3qzg X67Cyclin-dependent kinase 2 2.7.11.22 0.651
2g2h P16Tyrosine-protein kinase ABL1 2.7.10.2 0.650
3lfs A07Cyclin-dependent kinase 2 2.7.11.22 0.650
3unk 0BYCyclin-dependent kinase 2 2.7.11.22 0.650