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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1pmv 537 Mitogen-activated protein kinase 10 2.7.11.24

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1pmv 537Mitogen-activated protein kinase 10 2.7.11.24 0.966
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.721
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.703
3l9m L9McAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.702
3l9n L9NcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.701
1q41 IXMGlycogen synthase kinase-3 beta 2.7.11.26 0.687
3ma3 01ISerine/threonine-protein kinase pim-1 2.7.11.1 0.685
5av4 GENDeath-associated protein kinase 1 2.7.11.1 0.680
2uzt SS3cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
2uzw SS4cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.678
5auz GENDeath-associated protein kinase 1 2.7.11.1 0.678
4nbb 9CATerminal oxygenase component of carbazole / 0.675
2obj VRVSerine/threonine-protein kinase pim-1 2.7.11.1 0.674
2vth LZ2Cyclin-dependent kinase 2 2.7.11.22 0.674
3pcf FHBProtocatechuate 3,4-dioxygenase beta chain 1.13.11.3 0.674
3f88 3HTGlycogen synthase kinase-3 beta 2.7.11.26 0.672
2jds L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
1pmu 9HPMitogen-activated protein kinase 10 2.7.11.24 0.662
3qqg X06Cyclin-dependent kinase 2 2.7.11.22 0.662
4e5f 0N7Polymerase acidic protein / 0.660
1m2r MNYCasein kinase II subunit alpha 2.7.11.1 0.659
3fko FKOMitogen-activated protein kinase 14 / 0.659
1m2p HNACasein kinase II subunit alpha 2.7.11.1 0.656
3bgq VX2Serine/threonine-protein kinase pim-1 2.7.11.1 0.655
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.654
3i5z Z48Mitogen-activated protein kinase 1 2.7.11.24 0.654
3vqh IQBcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
4fx3 60KCyclin-dependent kinase 2 2.7.11.22 0.654
4neu Q1AReceptor-interacting serine/threonine-protein kinase 1 2.7.11.1 0.654
2hxq 373Serine/threonine-protein kinase Chk1 2.7.11.1 0.653
2r64 740Cyclin-dependent kinase 2 2.7.11.22 0.653
3w1f 1O5Dual specificity protein kinase TTK 2.7.12.1 0.652
3qqh X0ACyclin-dependent kinase 2 2.7.11.22 0.651