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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1nzw NAI Aldehyde dehydrogenase, mitochondrial 1.2.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.206
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.090
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.048
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.997
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.974
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.914
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.903
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.876
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.873
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.821
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.820
4pxl NADAldehyde dehydrogenase3 / 0.817
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.807
4pt0 NADAldehyde dehydrogenase / 0.796
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.788
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.776
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.773
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.743
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.740
4i9b NADPutative betaine aldehyde dehyrogenase / 0.723
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.722
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.714
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.712
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.709
5eyu NADBetaine-aldehyde dehydrogenase / 0.709
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.702
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.701
4pt3 NDPAldehyde dehydrogenase / 0.701
4i8q NADPutative betaine aldehyde dehyrogenase / 0.700
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.696
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.695
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.692
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.689
5dib NADBetaine-aldehyde dehydrogenase / 0.678
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.677
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.677
3rhd NAPLactaldehyde dehydrogenase 1.2.1.22 0.676
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.673
5ez4 NADBetaine-aldehyde dehydrogenase / 0.673
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.670
3b4w NADAldehyde dehydrogenase family protein / 0.667
3iwj NADAminoaldehyde dehydrogenase / 0.665
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.665
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.663
4f3x NADPutative aldehyde dehydrogenase / 0.662
4pz2 NADAldehyde dehydrogenase 2-6 / 0.662
2wme NAPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.660
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.657
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.655
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.654
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.654
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.653
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.651