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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1nxk STU MAP kinase-activated protein kinase 2 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1nxk STUMAP kinase-activated protein kinase 2 2.7.11.1 1.089
4kik KSAInhibitor of nuclear factor kappa-B kinase subunit beta 2.7.11.10 0.853
3a62 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.850
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.841
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.812
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.808
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.800
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.773
3bkb STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.773
5e8x STUTGF-beta receptor type-1 2.7.11.30 0.767
1xjd STUProtein kinase C theta type 2.7.11.13 0.766
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.756
2j0m 4STFocal adhesion kinase 1 2.7.10.2 0.755
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.748
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.741
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.737
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.734
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.729
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.720
3ckx STUSerine/threonine-protein kinase 24 2.7.11.1 0.704
1snu STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.700
2buj STUSerine/threonine-protein kinase 16 / 0.699
3cbl STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.698
4erw STUCyclin-dependent kinase 2 2.7.11.22 0.689
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.680
4ftt 6HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.679
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.676
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.674
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.674
4u9a STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.672
2io6 330Wee1-like protein kinase 2.7.10.2 0.668
2r0p K2CPutative FAD-monooxygenase / 0.668
3qwj X6ACyclin-dependent kinase 2 2.7.11.22 0.668
1nvs UCMSerine/threonine-protein kinase Chk1 2.7.11.1 0.667
1q8u H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.666
3unk 0BYCyclin-dependent kinase 2 2.7.11.22 0.665
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.662
2wtd ZZKSerine/threonine-protein kinase Chk2 2.7.11.1 0.660
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.660
4e5f 0N7Polymerase acidic protein / 0.660
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 0.659
3tku M77Serine/threonine-protein kinase MRCK beta 2.7.11.1 0.658
3a60 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.657
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.657
3a4o STUTyrosine-protein kinase Lyn 2.7.10.2 0.656
2uzt SS3cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
3fz1 B98Cyclin-dependent kinase 2 2.7.11.22 0.654
3rm6 18ZCyclin-dependent kinase 2 2.7.11.22 0.654
4ijp 1EHSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.653
4ftk H9KSerine/threonine-protein kinase Chk1 2.7.11.1 0.650