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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1nvs UCM Serine/threonine-protein kinase Chk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1nvs UCMSerine/threonine-protein kinase Chk1 2.7.11.1 0.997
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.872
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.809
4wsq KSAAP2-associated protein kinase 1 2.7.11.1 0.809
1oky STU3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.781
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.767
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 0.761
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1m3q ANGN-glycosylase/DNA lyase 3.2.2 0.744
2puc GUNHTH-type transcriptional repressor PurR / 0.744
4e5l DBHPolymerase acidic protein / 0.744
4ek9 EP4Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.744
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.738
1xjd STUProtein kinase C theta type 2.7.11.13 0.730
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.726
3a62 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.723
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.721
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.719
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.718
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.716
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.705
4yzc STUSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.702
4mvf STUCalcium-dependent protein kinase 2 2.7.11.1 0.701
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.700
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.696
2hy8 1STSerine/threonine-protein kinase PAK 1 2.7.11.1 0.693
3ckx STUSerine/threonine-protein kinase 24 2.7.11.1 0.693
2r0u M54Serine/threonine-protein kinase Chk1 2.7.11.1 0.691
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.690
4u9a STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.690
1q3d STUGlycogen synthase kinase-3 beta 2.7.11.26 0.675
4bie IE6Mitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.675
3dtc VINMitogen-activated protein kinase kinase kinase 9 2.7.11.25 0.672
3nuy JPZ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.670
1nxk STUMAP kinase-activated protein kinase 2 2.7.11.1 0.667
3nun JMZ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.666
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.664
1ozq PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1ulb GUNPurine nucleoside phosphorylase 2.4.2.1 0.660
2pot GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2pwu GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3bld PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4gcx PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4h7z GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hqv QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hvx QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3qcx 3Q23-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.658
1yhs STUSerine/threonine-protein kinase pim-1 2.7.11.1 0.655
3t9i 3T9Serine/threonine-protein kinase pim-1 2.7.11.1 0.653
1zys 199Serine/threonine-protein kinase Chk1 2.7.11.1 0.651