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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1nvr STU Serine/threonine-protein kinase Chk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 1.184
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 1.118
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 0.946
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.939
1oky STU3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.930
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.930
1stc STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.906
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.894
1nvs UCMSerine/threonine-protein kinase Chk1 2.7.11.1 0.872
4yzc STUSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.870
3cbl STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.837
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.832
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.829
4wsq KSAAP2-associated protein kinase 1 2.7.11.1 0.828
3ckx STUSerine/threonine-protein kinase 24 2.7.11.1 0.820
3f69 XDRSerine/threonine-protein kinase PknB 2.7.11.1 0.816
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.814
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.812
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.809
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.797
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.797
3bkb STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.795
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.783
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.782
1q3d STUGlycogen synthase kinase-3 beta 2.7.11.26 0.778
1xjd STUProtein kinase C theta type 2.7.11.13 0.775
4mvf STUCalcium-dependent protein kinase 2 2.7.11.1 0.771
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.769
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.768
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.767
5e8x STUTGF-beta receptor type-1 2.7.11.30 0.767
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.749
1byg STUTyrosine-protein kinase CSK / 0.747
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.745
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4u9a STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.744
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.726
1yhs STUSerine/threonine-protein kinase pim-1 2.7.11.1 0.718
3l8p 0CEAngiopoietin-1 receptor 2.7.10.1 0.716
3a62 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.710
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.705
2j0k 4STFocal adhesion kinase 1 2.7.10.2 0.705
4qmy STUSerine/threonine-protein kinase 24 2.7.11.1 0.704
3nuy JPZ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.692
2c1a I5ScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
4bid IE8Mitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.688
1uu3 LY43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.680
1nxk STUMAP kinase-activated protein kinase 2 2.7.11.1 0.676
2erz HFScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
1zys 199Serine/threonine-protein kinase Chk1 2.7.11.1 0.671
4e5f 0N7Polymerase acidic protein / 0.660
2qhm 7CSSerine/threonine-protein kinase Chk1 2.7.11.1 0.659
4b0g VEKAurora kinase A 2.7.11.1 0.659
2ym5 YM5Serine/threonine-protein kinase Chk1 2.7.11.1 0.657
4e4n 0NLTyrosine-protein kinase JAK1 / 0.657
3dtc VINMitogen-activated protein kinase kinase kinase 9 2.7.11.25 0.655
1ydr IQPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
3tku M77Serine/threonine-protein kinase MRCK beta 2.7.11.1 0.653