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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1jtv TES Estradiol 17-beta-dehydrogenase 1 1.1.1.62

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1jtv TESEstradiol 17-beta-dehydrogenase 1 1.1.1.62 1.030
3dey DHTEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.762
3klm DHTEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.762
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1qyx ASDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.743
1qyw 5SDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.723
4e5l DBHPolymerase acidic protein / 0.715
1kdm DHTSex hormone-binding globulin / 0.710
2piu DHTAndrogen receptor / 0.700
2pit DHTAndrogen receptor / 0.696
4ofr DHTAndrogen receptor / 0.694
3cot STR3-oxo-5-beta-steroid 4-dehydrogenase / 0.688
2piv DHTAndrogen receptor / 0.686
2pkl DHTAndrogen receptor / 0.685
2z4j DHTAndrogen receptor / 0.685
2ylo TESAndrogen receptor / 0.682
1lho AOMSex hormone-binding globulin / 0.680
3w5q 3KLVitamin D3 receptor / 0.680
3g1r FIT3-oxo-5-beta-steroid 4-dehydrogenase / 0.679
2piw DHTAndrogen receptor / 0.672
1lri CLRBeta-elicitin cryptogein / 0.670
1t5z DHTAndrogen receptor / 0.670
1t7r DHTAndrogen receptor / 0.670
4oea DHTAndrogen receptor / 0.670
1lhu ESTSex hormone-binding globulin / 0.669
2pio DHTAndrogen receptor / 0.669
2q7k TESAndrogen receptor / 0.669
1coy ANDCholesterol oxidase 1.1.3.6 0.668
1t74 DHTAndrogen receptor / 0.667
3cmf PDN3-oxo-5-beta-steroid 4-dehydrogenase / 0.666
1t7t DHTAndrogen receptor / 0.665
2qpy DHTAndrogen receptor / 0.665
2fzk CTPAspartate carbamoyltransferase regulatory chain / 0.664
2ylp TESAndrogen receptor / 0.664
2abi 1CAMineralocorticoid receptor / 0.663
3s79 ASDAromatase 1.14.14.14 0.663
1t63 DHTAndrogen receptor / 0.661
2ama DHTAndrogen receptor / 0.661
2y00 Y01Beta-1 adrenergic receptor / 0.661
1t7f DHTAndrogen receptor / 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4j6b PLOCytochrome P450 monooxygenase / 0.659
4q0a 4OAVitamin D3 receptor A / 0.659
2oax SNLMineralocorticoid receptor / 0.658
2q7l TESAndrogen receptor / 0.657
1t73 DHTAndrogen receptor / 0.656
2aa6 STRMineralocorticoid receptor / 0.656
1d2s DHTSex hormone-binding globulin / 0.653
1lhn AONSex hormone-binding globulin / 0.653
2yhd TESAndrogen receptor / 0.653
4oed DHTAndrogen receptor / 0.653
5dxg ESTEstrogen receptor / 0.650
5hyr ESTEstrogen receptor / 0.650