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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1jst ATP Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1jst ATPCyclin-dependent kinase 2 2.7.11.22 0.967
5l6w AGSLIM domain kinase 1 2.7.11.1 0.699
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.684
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.683
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.679
2pul ACPMethylthioribose kinase 2.7.1.100 0.675
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.665
2olc ADPMethylthioribose kinase 2.7.1.100 0.662
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.662
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.660
4qny ANPMitogen activated protein kinase, putative / 0.660
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.660
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.658
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.658
3qc9 ADPRhodopsin kinase / 0.656
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.655
2pui ADPMethylthioribose kinase 2.7.1.100 0.655
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.655
2dxv SAHDiphthine synthase / 0.653
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.653
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.652
4riy ADPEpidermal growth factor receptor 2.7.10.1 0.651