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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1jqh ANP Insulin-like growth factor 1 receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1jqh ANPInsulin-like growth factor 1 receptor 2.7.10.1 0.874
1i44 ACPInsulin receptor 2.7.10.1 0.709
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.698
1mqb ANPEphrin type-A receptor 2 2.7.10.1 0.690
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.683
4f1m ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.682
3lij ANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands / 0.676
1u54 ACPActivated CDC42 kinase 1 / 0.675
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.672
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.672
4s34 ANPMitogen-activated protein kinase 1 2.7.11.24 0.672
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.670
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.669
3q5i ANPProtein kinase, putative / 0.669
4gt3 ATPMitogen-activated protein kinase 1 2.7.11.24 0.668
1zy5 ANPeIF-2-alpha kinase GCN2 / 0.665
2qoc ANPEphrin type-A receptor 3 2.7.10.1 0.665
1fin ATPCyclin-dependent kinase 2 2.7.11.22 0.663
3d5w ADPSerine/threonine-protein kinase PLK / 0.663
4q5h ANPProtein kinase OspG 2.7 0.662
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.661
3qyw 6PBMitogen-activated protein kinase 1 2.7.11.24 0.660
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.659
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.658
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.658
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.656
5csh ATPCasein kinase II subunit alpha 2.7.11.1 0.655
4f0f ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.654
4s32 ANPMitogen-activated protein kinase 1 2.7.11.24 0.654
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.653
4uya AGSMitogen-activated protein kinase kinase kinase 21 2.7.11.25 0.653
1w8c N69Cyclin-dependent kinase 2 2.7.11.22 0.652
4fkl CK2Cyclin-dependent kinase 2 2.7.11.22 0.651
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.651
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.650