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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1jmf UMP Thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1jmf UMPThymidylate synthase / 0.940
1tsy UMPThymidylate synthase / 0.793
4e5o UMPThymidylate synthase 2.1.1.45 0.790
3dg8 UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.789
2fto TMPThymidylate synthase / 0.787
1vzb UMPThymidylate synthase / 0.782
1jmg UMPThymidylate synthase / 0.776
4dq1 UMPThymidylate synthase / 0.775
1njc DCMThymidylate synthase / 0.766
1nja DCMThymidylate synthase / 0.764
1tsx UMPThymidylate synthase / 0.764
1j3j UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.762
1f28 UMPThymidylate synthase 2.1.1.45 0.750
1bid UMPThymidylate synthase / 0.748
1vza UMPThymidylate synthase / 0.747
1b5e DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.745
4isk UMPThymidylate synthase / 0.744
3qj7 UMPThymidylate synthase ThyA / 0.743
4ein NOHThymidylate synthase 2.1.1.45 0.741
3dga UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.740
1bp0 UMPThymidylate synthase / 0.739
2g86 UMPThymidylate synthase / 0.735
4eil UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.733
1b5d DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.729
1bp6 UMPThymidylate synthase / 0.724
4dpd UMPBifunctional dihydrofolate reductase-thymidylate synthase / 0.723
2g89 UMPThymidylate synthase / 0.717
2tdm UMPThymidylate synthase / 0.716
1tys TMPThymidylate synthase / 0.714
1tsv UMPThymidylate synthase / 0.713
4h0u UMPThymidylate synthase / 0.709
1jmi UMPThymidylate synthase / 0.707
5by6 UMPThymidylate synthase / 0.704
2tsr UMPThymidylate synthase 2.1.1.45 0.703
2vet UMPThymidylate synthase / 0.702
3bgx TMPThymidylate synthase / 0.700
4eb4 UMPThymidylate synthase 2.1.1.45 0.696
1njd UMPThymidylate synthase / 0.693
4irr UMPThymidylate synthase / 0.693
1jmh UMPThymidylate synthase / 0.685
1bpj UMPThymidylate synthase / 0.678
4fox UMPThymidylate synthase ThyA / 0.676
4psg NOHThymidylate synthase / 0.676
1tdc UMPThymidylate synthase / 0.675
2g8a UMPThymidylate synthase / 0.674
3fvu IACKynurenine--oxoglutarate transaminase 1 2.6.1.7 0.659
3o5t ADPNitrogen regulatory protein P-II 1 / 0.652
7dfr FOLDihydrofolate reductase 1.5.1.3 0.651