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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1frb ZST Aldose reductase-related protein 2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1frb ZSTAldose reductase-related protein 2 / 1.113
2pd5 ZSTAldose reductase 1.1.1.21 0.906
2pdm ZSTAldose reductase 1.1.1.21 0.903
2pdi ZSTAldose reductase 1.1.1.21 0.896
2fz9 ZSTAldose reductase 1.1.1.21 0.876
4gca 2X9Aldose reductase 1.1.1.21 0.859
3len ZSTAldose reductase 1.1.1.21 0.845
3m0i ZSTAldose reductase 1.1.1.21 0.845
2pdg 47DAldose reductase 1.1.1.21 0.832
1z3n 3NAAldose reductase 1.1.1.21 0.830
2pdh 47DAldose reductase 1.1.1.21 0.827
2pdq 47DAldose reductase 1.1.1.21 0.818
2fz8 ZSTAldose reductase 1.1.1.21 0.806
2pdf ZSTAldose reductase 1.1.1.21 0.802
2pdn 47DAldose reductase 1.1.1.21 0.801
2pdb ZSTAldose reductase 1.1.1.21 0.789
2hvo ZSTAldose reductase 1.1.1.21 0.786
2dv0 ZSTAldose reductase 1.1.1.21 0.784
2hvn ZSTAldose reductase 1.1.1.21 0.784
2dux ZSTAldose reductase 1.1.1.21 0.782
3g5e Q74Aldose reductase 1.1.1.21 0.781
2hv5 ZSTAldose reductase 1.1.1.21 0.772
2pzn 393Aldose reductase 1.1.1.21 0.771
2duz ZSTAldose reductase 1.1.1.21 0.761
3mb9 ZSTAldose reductase 1.1.1.21 0.748
2pdx ZSTAldose reductase 1.1.1.21 0.735
2pdu 393Aldose reductase 1.1.1.21 0.726
2pdp 393Aldose reductase 1.1.1.21 0.720
2pdj 393Aldose reductase 1.1.1.21 0.719
3ld5 LDTAldose reductase 1.1.1.21 0.714
3lbo LDTAldose reductase 1.1.1.21 0.691
3ght LDTAldose reductase 1.1.1.21 0.684
3ghu LDTAldose reductase 1.1.1.21 0.684
3m64 393Aldose reductase 1.1.1.21 0.680
3t42 3T4Aldose reductase 1.1.1.21 0.680
1t40 ID5Aldose reductase 1.1.1.21 0.677
3ghr LDTAldose reductase 1.1.1.21 0.676
3ghs LDTAldose reductase 1.1.1.21 0.676
1us0 LDTAldose reductase 1.1.1.21 0.673
2i16 LDTAldose reductase 1.1.1.21 0.673
2i17 LDTAldose reductase 1.1.1.21 0.673
2nvc ITAAldose reductase 1.1.1.21 0.673
2qxw LDTAldose reductase 1.1.1.21 0.673
2ipw 2CLAldose reductase 1.1.1.21 0.668
2ikh LITAldose reductase 1.1.1.21 0.665
2inz OHPAldose reductase 1.1.1.21 0.656
2pdc 393Aldose reductase 1.1.1.21 0.654
2ikj 393Aldose reductase 1.1.1.21 0.653