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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1efk NAD NAD-dependent malic enzyme, mitochondrial 1.1.1.38

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1efk NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 1.032
1do8 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.950
1efl NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.904
1pj3 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.881
1gq2 NAPNADP-dependent malic enzyme 1.1.1.40 0.862
1pj2 NAINAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.851
1gz4 ATPNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.722
1llq NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.719
1qr6 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.713
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.700
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.699
3d64 NADAdenosylhomocysteinase / 0.693
1pj4 ATPNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.690
4k28 NADShikimate dehydrogenase family protein / 0.684
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.682
4c4o NADSADH / 0.682
2o4c NADErythronate-4-phosphate dehydrogenase / 0.677
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.677
1yl7 NAI4-hydroxy-tetrahydrodipicolinate reductase / 0.675
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.673
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.673
1b3r NADAdenosylhomocysteinase 3.3.1.1 0.668
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.668
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.667
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.660
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.659
1o6z NADMalate dehydrogenase / 0.658
4tvb NADHomospermidine synthase 2.5.1.44 0.658
2fkn NADUrocanate hydratase 4.2.1.49 0.655
4xqc NADHomospermidine synthase 2.5.1.44 0.655
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.654
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.654
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.654
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.654
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.653
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.652
4b7x NAPProbable oxidoreductase / 0.652
1uxj NADMalate dehydrogenase / 0.651
4xq9 NADHomospermidine synthase 2.5.1.44 0.651