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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1dyi FOL Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1dyi FOLDihydrofolate reductase 1.5.1.3 0.973
1dyh DZFDihydrofolate reductase 1.5.1.3 0.953
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.946
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.928
4kjj FOLDihydrofolate reductase 1.5.1.3 0.924
4x5f FOLDihydrofolate reductase 1.5.1.3 0.922
4x5g FOLDihydrofolate reductase 1.5.1.3 0.915
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.891
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.890
4i13 FOLDihydrofolate reductase 1.5.1.3 0.882
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.878
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.873
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.859
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.854
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.843
4i1n FOLDihydrofolate reductase 1.5.1.3 0.841
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.840
7dfr FOLDihydrofolate reductase 1.5.1.3 0.836
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.830
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.821
4x5h FOLDihydrofolate reductase 1.5.1.3 0.821
2zza FOLDihydrofolate reductase / 0.818
3tqb FOLDihydrofolate reductase / 0.818
1dyj DDFDihydrofolate reductase 1.5.1.3 0.805
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.805
4fhb FOLDihydrofolate reductase 1.5.1.3 0.804
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.803
4m6k FOLDihydrofolate reductase 1.5.1.3 0.794
1drf FOLDihydrofolate reductase 1.5.1.3 0.793
1hfr MOTDihydrofolate reductase 1.5.1.3 0.788
1hfq MOTDihydrofolate reductase 1.5.1.3 0.786
5ccc DDFDihydrofolate reductase 1.5.1.3 0.786
1jom FFODihydrofolate reductase 1.5.1.3 0.784
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.783
1tdr MTXDihydrofolate reductase 1.5.1.3 0.776
4x5i FOLDihydrofolate reductase 1.5.1.3 0.775
1re7 FOLDihydrofolate reductase 1.5.1.3 0.773
1jol FFODihydrofolate reductase 1.5.1.3 0.771
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.771
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.769
4kfj FOLDihydrofolate reductase 1.5.1.3 0.769
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.767
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.766
1dhj MTXDihydrofolate reductase 1.5.1.3 0.760
5hi6 MTXDihydrofolate reductase / 0.760
2d0k FOLDihydrofolate reductase 1.5.1.3 0.759
3drc MTXDihydrofolate reductase 1.5.1.3 0.759
3och 2MXDihydrofolate reductase 1.5.1.3 0.756
1dra MTXDihydrofolate reductase 1.5.1.3 0.755
1df7 MTXDihydrofolate reductase 1.5.1.3 0.753
1dls MTXDihydrofolate reductase 1.5.1.3 0.752
1drb MTXDihydrofolate reductase 1.5.1.3 0.751
3tq9 MTXDihydrofolate reductase / 0.749
1u70 MTXDihydrofolate reductase 1.5.1.3 0.748
1dhf FOLDihydrofolate reductase 1.5.1.3 0.747
3ghv GHCDihydrofolate reductase 1.5.1.3 0.747
2w3m FOLDihydrofolate reductase 1.5.1.3 0.743
3dfr MTXDihydrofolate reductase 1.5.1.3 0.741
1e26 GPBDihydrofolate reductase 1.5.1.3 0.734
4m6l 21VDihydrofolate reductase 1.5.1.3 0.733
3dau MTXDihydrofolate reductase 1.5.1.3 0.730
1hfp MOTDihydrofolate reductase 1.5.1.3 0.728
4p66 MTXDihydrofolate reductase / 0.727
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.726
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.726
2qk8 MTXDihydrofolate reductase / 0.724
1ao8 MTXDihydrofolate reductase 1.5.1.3 0.723
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.723
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.723
4dfr MTXDihydrofolate reductase 1.5.1.3 0.723
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.722
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.722
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.720
4qi9 MTXDihydrofolate reductase / 0.718
1dre MTXDihydrofolate reductase 1.5.1.3 0.716
2drc MTXDihydrofolate reductase 1.5.1.3 0.712
4keb FOLDihydrofolate reductase 1.5.1.3 0.712
1dhi MTXDihydrofolate reductase 1.5.1.3 0.704
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.704
1dds MTXDihydrofolate reductase 1.5.1.3 0.701
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.701
1u72 MTXDihydrofolate reductase 1.5.1.3 0.700
3eig MTXDihydrofolate reductase 1.5.1.3 0.697
4p68 MTXDihydrofolate reductase / 0.694
2dhf DZFDihydrofolate reductase 1.5.1.3 0.691
4x5j FOLDihydrofolate reductase 1.5.1.3 0.679
3ia4 MTXDihydrofolate reductase / 0.673
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.672
1ohj COPDihydrofolate reductase 1.5.1.3 0.671
2tpl HPPTyrosine phenol-lyase 4.1.99.2 0.671
3frd DHFDihydrofolate reductase 1.5.1.3 0.670
3ghw GHWDihydrofolate reductase 1.5.1.3 0.665
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.664
1drt PCVClavaminate synthase 1 1.14.11.21 0.662
3dat MTXDihydrofolate reductase / 0.660
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.660
3zzf NLGProtein ARG5,6, mitochondrial 2.7.2.8 0.660
4eil FOLBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.656
1ddr MTXDihydrofolate reductase 1.5.1.3 0.651
4ie5 MD6Alpha-ketoglutarate-dependent dioxygenase FTO / 0.651