Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1dls MTX Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1dls MTXDihydrofolate reductase 1.5.1.3 1.091
3dau MTXDihydrofolate reductase 1.5.1.3 0.918
1u70 MTXDihydrofolate reductase 1.5.1.3 0.882
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.879
1hfr MOTDihydrofolate reductase 1.5.1.3 0.871
4dfr MTXDihydrofolate reductase 1.5.1.3 0.870
2drc MTXDihydrofolate reductase 1.5.1.3 0.869
3ia4 MTXDihydrofolate reductase / 0.866
1dra MTXDihydrofolate reductase 1.5.1.3 0.857
3och 2MXDihydrofolate reductase 1.5.1.3 0.855
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.854
4p66 MTXDihydrofolate reductase / 0.854
5hi6 MTXDihydrofolate reductase / 0.854
1hfq MOTDihydrofolate reductase 1.5.1.3 0.853
3drc MTXDihydrofolate reductase 1.5.1.3 0.849
3eig MTXDihydrofolate reductase 1.5.1.3 0.849
3tq9 MTXDihydrofolate reductase / 0.846
2zza FOLDihydrofolate reductase / 0.838
1df7 MTXDihydrofolate reductase 1.5.1.3 0.832
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.827
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.824
3dfr MTXDihydrofolate reductase 1.5.1.3 0.823
2qk8 MTXDihydrofolate reductase / 0.817
4i1n FOLDihydrofolate reductase 1.5.1.3 0.813
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.807
4m6k FOLDihydrofolate reductase 1.5.1.3 0.807
1drf FOLDihydrofolate reductase 1.5.1.3 0.805
1ohj COPDihydrofolate reductase 1.5.1.3 0.804
1dhj MTXDihydrofolate reductase 1.5.1.3 0.799
4qi9 MTXDihydrofolate reductase / 0.794
1ohk COPDihydrofolate reductase 1.5.1.3 0.789
1tdr MTXDihydrofolate reductase 1.5.1.3 0.786
1hfp MOTDihydrofolate reductase 1.5.1.3 0.785
1e26 GPBDihydrofolate reductase 1.5.1.3 0.780
1u72 MTXDihydrofolate reductase 1.5.1.3 0.779
1drb MTXDihydrofolate reductase 1.5.1.3 0.775
1dhi MTXDihydrofolate reductase 1.5.1.3 0.774
4i13 FOLDihydrofolate reductase 1.5.1.3 0.765
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.762
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.760
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.760
1dre MTXDihydrofolate reductase 1.5.1.3 0.752
1dyi FOLDihydrofolate reductase 1.5.1.3 0.752
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.750
2fzi DH3Dihydrofolate reductase 1.5.1.3 0.749
2d0k FOLDihydrofolate reductase 1.5.1.3 0.748
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.741
3dat MTXDihydrofolate reductase / 0.738
4x5i FOLDihydrofolate reductase 1.5.1.3 0.738
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.737
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.736
1dhf FOLDihydrofolate reductase 1.5.1.3 0.731
3td8 D2RDihydrofolate reductase 1.5.1.3 0.730
3ghw GHWDihydrofolate reductase 1.5.1.3 0.725
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.719
4ixg IXGDihydrofolate reductase 1.5.1.3 0.718
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.710
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.709
7dfr FOLDihydrofolate reductase 1.5.1.3 0.709
4p68 MTXDihydrofolate reductase / 0.707
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.704
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.702
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.701
4x5f FOLDihydrofolate reductase 1.5.1.3 0.700
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.699
1jom FFODihydrofolate reductase 1.5.1.3 0.698
4x5g FOLDihydrofolate reductase 1.5.1.3 0.697
2w3m FOLDihydrofolate reductase 1.5.1.3 0.696
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.696
4x5h FOLDihydrofolate reductase 1.5.1.3 0.693
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.691
3ghv GHCDihydrofolate reductase 1.5.1.3 0.689
2fzj DH3Dihydrofolate reductase 1.5.1.3 0.688
1dds MTXDihydrofolate reductase 1.5.1.3 0.683
3frd DHFDihydrofolate reductase 1.5.1.3 0.681
4fhb FOLDihydrofolate reductase 1.5.1.3 0.676
1ddr MTXDihydrofolate reductase 1.5.1.3 0.672
4kjj FOLDihydrofolate reductase 1.5.1.3 0.672
2dhf DZFDihydrofolate reductase 1.5.1.3 0.671
4m6l 21VDihydrofolate reductase 1.5.1.3 0.670
1klk PMDDihydrofolate reductase 1.5.1.3 0.668
4kfj FOLDihydrofolate reductase 1.5.1.3 0.668
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.666
4keb FOLDihydrofolate reductase 1.5.1.3 0.666
1kms LIHDihydrofolate reductase 1.5.1.3 0.665
1pd9 CO4Dihydrofolate reductase 1.5.1.3 0.665
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.664
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.664
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.663
1mvt DTMDihydrofolate reductase 1.5.1.3 0.661
1dyh DZFDihydrofolate reductase 1.5.1.3 0.659
4nhm UN9Prolyl 3,4-dihydroxylase TPA1 1.14.11 0.659
1dyj DDFDihydrofolate reductase 1.5.1.3 0.656
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.655
1s3v TQDDihydrofolate reductase 1.5.1.3 0.655
2w3v TOPDihydrofolate reductase / 0.654
1aoe GW3Dihydrofolate reductase 1.5.1.3 0.653
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.653
4eil FOLBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.652
3nxo D2BDihydrofolate reductase 1.5.1.3 0.651