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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1dg8 NDP Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1dg8 NDPDihydrofolate reductase 1.5.1.3 1.355
4kl9 NDPDihydrofolate reductase 1.5.1.3 1.238
2cig 1DGDihydrofolate reductase 1.5.1.3 1.235
3dga NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 1.031
5ecc NAPDehydrofolate reductase type I / 0.999
3clb NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.959
3inv NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.958
3kjs NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.948
3tqa NDPDihydrofolate reductase / 0.915
1rx1 NAPDihydrofolate reductase 1.5.1.3 0.900
1j3j NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.892
1drh NAPDihydrofolate reductase 1.5.1.3 0.888
3qls NDPDihydrofolate reductase 1.5.1.3 0.883
3dg8 NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.881
3kjr NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.871
3nxx NDPDihydrofolate reductase 1.5.1.3 0.863
2h2q NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.861
1m78 NDPDihydrofolate reductase 1.5.1.3 0.842
3d84 NDPDihydrofolate reductase 1.5.1.3 0.836
1dr5 NAPDihydrofolate reductase 1.5.1.3 0.829
1dr3 TAPDihydrofolate reductase 1.5.1.3 0.827
1ai9 NDPDihydrofolate reductase 1.5.1.3 0.819
1j3k NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.818
4m6j NDPDihydrofolate reductase 1.5.1.3 0.807
2w3b NDPDihydrofolate reductase 1.5.1.3 0.804
1dr2 TAPDihydrofolate reductase 1.5.1.3 0.791
8dfr NDPDihydrofolate reductase 1.5.1.3 0.781
3qlr NDPDihydrofolate reductase 1.5.1.3 0.762
1ia1 NDPDihydrofolate reductase 1.5.1.3 0.728
4ha9 NDP2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase 1.1.1.302 0.717
1rx6 NAPDihydrofolate reductase 1.5.1.3 0.697
3hbb NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.676
4xt6 NAPPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc / 0.668
3cgb COACoenzyme A disulfide reductase / 0.651
3s87 DGTRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.650