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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ah0 SBI Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1ah0 SBIAldose reductase 1.1.1.21 0.856
4e5i 0N9Polymerase acidic protein / 0.744
4gab FIDAldo-keto reductase family 1 member B10 1.1.1 0.715
4ga8 SBIAldo-keto reductase family 1 member B10 1.1.1 0.698
2pd9 FIDAldose reductase 1.1.1.21 0.695
3h4g FIDAlcohol dehydrogenase [NADP(+)] 1.1.1.2 0.695
2agt FIDAldose reductase 1.1.1.21 0.694
2pdk SBIAldose reductase 1.1.1.21 0.681
2pdw FIDAldose reductase 1.1.1.21 0.677
2pdy FIDAldose reductase 1.1.1.21 0.672
1pwm FIDAldose reductase 1.1.1.21 0.664
4e5f 0N7Polymerase acidic protein / 0.660
1ef3 FIDAldose reductase 1.1.1.21 0.659
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.652
1wet GUNHTH-type transcriptional repressor PurR / 0.651