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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5iu4ZMAAdenosine receptor A2a

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5iu4ZMAAdenosine receptor A2a/1.000
5iua6DXAdenosine receptor A2a/0.885
5iubCLRAdenosine receptor A2a/0.709
5uviZMAAdenosine receptor A2a/0.638
5iu86DZAdenosine receptor A2a/0.630
5k2bZMAAdenosine receptor A2a/0.627
4eiyZMAAdenosine receptor A2a/0.615
3emlZMAAdenosine receptor A2a/0.592
5k2cZMAAdenosine receptor A2a/0.582
5k2dZMAAdenosine receptor A2a/0.582
5k2aZMAAdenosine receptor A2a/0.578
5jtbZMAAdenosine receptor A2a/0.568
2ydoADNAdenosine receptor A2a/0.499
2ydvNECAdenosine receptor A2a/0.499
4uhrNGIAdenosine receptor A2a/0.477
4ug2NGIAdenosine receptor A2a/0.474
5g53NECAdenosine receptor A2a/0.470
3vg9ZMAAdenosine receptor A2a/0.465
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.458
1a4iNDPC-1-tetrahydrofolate synthase, cytoplasmic1.5.1.50.452
1ia4TQ6Dihydrofolate reductase1.5.1.30.451
4at0FADPossible succinate dehydrogenase/0.448
3rfmCFFAdenosine receptor A2a/0.446
1fm4DXCMajor pollen allergen Bet v 1-L/0.443
3w0gW07Vitamin D3 receptor/0.440