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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5hidB1ESerine/threonine-protein kinase B-raf2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5hidB1ESerine/threonine-protein kinase B-raf2.7.11.11.000
4h1m0YJProtein-tyrosine kinase 2-beta2.7.10.20.534
5hi2BAXSerine/threonine-protein kinase B-raf2.7.11.10.522
1wbsLI2Mitogen-activated protein kinase 14/0.509
1kv2B96Mitogen-activated protein kinase 14/0.502
2e2b406Tyrosine-protein kinase ABL12.7.10.20.502
3gcuR48Mitogen-activated protein kinase 14/0.499
3gcvSS6Mitogen-activated protein kinase 14/0.490
3hv6R39Mitogen-activated protein kinase 14/0.490
3o8uBMUMitogen-activated protein kinase 14/0.490
3uvr06FMitogen-activated protein kinase 14/0.483
3vhe42QVascular endothelial growth factor receptor 22.7.10.10.482
1kv1BMUMitogen-activated protein kinase 14/0.481
3p7bP7BMitogen-activated protein kinase 14/0.474
3p7cP7CMitogen-activated protein kinase 14/0.474
3wzeBAXVascular endothelial growth factor receptor 22.7.10.10.472
3nnuEDBMitogen-activated protein kinase 14/0.467
2b00GCHPhospholipase A2, major isoenzyme3.1.1.40.464
4hw764MMacrophage colony-stimulating factor 1 receptor2.7.10.10.463
3d83GK6Mitogen-activated protein kinase 14/0.461
2hznKINTyrosine-protein kinase ABL12.7.10.20.460
4r7iSTIMacrophage colony-stimulating factor 1 receptor2.7.10.10.460
1wbnL09Mitogen-activated protein kinase 14/0.459
2hiw7MPTyrosine-protein kinase ABL12.7.10.20.459
2yisYISMitogen-activated protein kinase 14/0.459
3hv4L51Mitogen-activated protein kinase 14/0.459
4asdBAXVascular endothelial growth factor receptor 22.7.10.10.459
5dpvSKEAurora kinase A2.7.11.10.458
2ckeIQUDeath-associated protein kinase 2/0.454
3cs9NILTyrosine-protein kinase ABL12.7.10.20.454
3nnwEDDMitogen-activated protein kinase 14/0.454
3nux3NVCyclin-dependent kinase 62.7.11.220.453
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.453
3qw2NADMyo-inositol-1-phosphate synthase (Ino1)/0.452
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.450
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
3mv5XFERAC-alpha serine/threonine-protein kinase2.7.11.10.448
4jajXU1Aurora kinase A2.7.11.10.448
2j5xGSPADP-ribosylation factor 6/0.447
3e9319BMitogen-activated protein kinase 14/0.447
3p7aP7AMitogen-activated protein kinase 14/0.445
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
1wbtWBTMitogen-activated protein kinase 14/0.443
1fvv107Cyclin-dependent kinase 22.7.11.220.442
4dtaADNAPH(2'')-Id/0.442
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
1rdwLARActin, alpha skeletal muscle/0.441
1tezFADDeoxyribodipyrimidine photo-lyase4.1.99.30.440
3nwq2NCGag-Pol polyprotein3.4.23.160.440