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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5e9eANPMyosin heavy chain kinase A2.7.11.7

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5e9eANPMyosin heavy chain kinase A2.7.11.71.000
4zs4ATPMyosin heavy chain kinase A2.7.11.70.630
3llaACPMyosin heavy chain kinase A2.7.11.70.619
4zmeADNMyosin heavy chain kinase A2.7.11.70.588
3lmhADPMyosin heavy chain kinase A2.7.11.70.573
3lmiATPMyosin heavy chain kinase A2.7.11.70.519
1ia9ANPTransient receptor potential cation channel subfamily M member 72.7.11.10.509
3pdtADPMyosin heavy chain kinase A2.7.11.70.495
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.477
2owb626Serine/threonine-protein kinase PLK12.7.11.210.469
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.461
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
4pnmNU1Tankyrase-22.4.2.300.451
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
1obnASVIsopenicillin N synthase1.21.3.10.446
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
3ufl508Beta-secretase 13.4.23.460.443