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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5cvfATPCasein kinase II subunit alpha2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5cvfATPCasein kinase II subunit alpha2.7.11.11.000
3mb714ICasein kinase II subunit alpha2.7.11.10.484
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.481
3q9xEMOCasein kinase II subunit alpha2.7.11.10.480
3axwTIDCasein kinase II subunit alpha2.7.11.10.472
3at4CCKCasein kinase II subunit alpha2.7.11.10.470
4grb0XGCasein kinase II subunit alpha2.7.11.10.467
1pjkANPCasein kinase II subunit alpha2.7.11.10.457
2yaaATPDeath-associated protein kinase 2/0.451
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.443