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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5c4iTPPOxalate oxidoreductase subunit alpha

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5c4iTPPOxalate oxidoreductase subunit alpha/1.000
5c4iTPPOxalate oxidoreductase subunit beta/1.000
2c3p1TPPyruvate synthase/0.537
2uzaHTLPyruvate synthase/0.529
2c3yHTLPyruvate synthase/0.524
1kekHTLPyruvate synthase/0.517
5exdTPPOxalate oxidoreductase subunit alpha/0.515
5exdTPPOxalate oxidoreductase subunit beta/0.515
2c42TPPPyruvate synthase/0.504
2c3oTPPPyruvate synthase/0.497
2pdaTPPPyruvate synthase/0.477
2c3u2TPPyruvate synthase/0.461
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
3ft8MOJHeat shock protein HSP 90-alpha/0.457
2ag0TPPBenzaldehyde lyase/0.456
4bfvZVVPantothenate kinase2.7.1.330.451
1um0FMNChorismate synthase/0.449
2fhnBNIAvidin-related protein 4/5/0.449
3mb714ICasein kinase II subunit alpha2.7.11.10.449
2yeiXQIHeat shock protein HSP 90-alpha/0.445
3qdd94MHeat shock protein HSP 90-alpha/0.443
2jlaTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.442
4zp1TPPPyruvate decarboxylase4.1.1.10.442
2q5oPPYIndole-3-pyruvate decarboxylase4.1.1.740.441
2g78REACellular retinoic acid-binding protein 2/0.440