sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4xlv	ACP	Insulin receptor	2.7.10.1

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
4xlv	ACP	Insulin receptor	2.7.10.1	1.000
3dqw	AGS	Proto-oncogene tyrosine-protein kinase Src	2.7.10.2	0.473
4qny	ANP	Mitogen activated protein kinase, putative	/	0.468
3bu5	ATP	Insulin receptor	2.7.10.1	0.458
4qml	ANP	Serine/threonine-protein kinase 24	2.7.11.1	0.458
2h8h	H8H	Proto-oncogene tyrosine-protein kinase Src	2.7.10.2	0.456
3gu7	ADP	Death-associated protein kinase 1	2.7.11.1	0.456
1jkk	ANP	Death-associated protein kinase 1	2.7.11.1	0.450
1qpj	STU	Tyrosine-protein kinase Lck	2.7.10.2	0.444