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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4xey1N1Tyrosine-protein kinase ABL12.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4xey1N1Tyrosine-protein kinase ABL12.7.10.21.000
2g2hP16Tyrosine-protein kinase ABL12.7.10.20.550
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.529
1bygSTUTyrosine-protein kinase CSK/0.522
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.485
3k5uPFQAurora kinase A2.7.11.10.480
4j98ACPFibroblast growth factor receptor 2/0.479
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.478
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.478
3ttiKBIMitogen-activated protein kinase 102.7.11.240.478
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.467
2qo9ANPEphrin type-A receptor 32.7.10.10.467
4jia1K3Tyrosine-protein kinase JAK2/0.467
4wkqIREEpidermal growth factor receptor2.7.10.10.466
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.465
2b1pAIZMitogen-activated protein kinase 102.7.11.240.464
4gk4L90Ephrin type-A receptor 32.7.10.10.464
4nk92K5Fibroblast growth factor receptor 1/0.464
2p33J07Mitogen-activated protein kinase 102.7.11.240.463
3ttjJBIMitogen-activated protein kinase 102.7.11.240.463
4g2fC07Ephrin type-A receptor 32.7.10.10.463
2hk51BMTyrosine-protein kinase HCK2.7.10.20.462
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.462
2of4979Tyrosine-protein kinase Lck2.7.10.20.461
2qocANPEphrin type-A receptor 32.7.10.10.461
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.461
5l8lADPAurora kinase A2.7.11.10.461
2vwu7X1Ephrin type-B receptor 42.7.10.10.459
3vs3VSETyrosine-protein kinase HCK2.7.10.20.459
2vwz7X6Ephrin type-B receptor 42.7.10.10.458
4bb432WEphrin type-B receptor 42.7.10.10.458
2xvdAS6Ephrin type-B receptor 42.7.10.10.457
4y93746Tyrosine-protein kinase/0.457
2y6o1N1Ephrin type-A receptor 42.7.10.10.456
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.455
2qo7ANPEphrin type-A receptor 32.7.10.10.454
2qoqANPEphrin type-A receptor 32.7.10.10.454
4gk3L87Ephrin type-A receptor 32.7.10.10.454
2vx17X8Ephrin type-B receptor 42.7.10.10.453
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.453
2vwy7X5Ephrin type-B receptor 42.7.10.10.452
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.451
4gk2L66Ephrin type-A receptor 32.7.10.10.451
4y95746Tyrosine-protein kinase/0.451
3vs1VSATyrosine-protein kinase HCK2.7.10.20.450
4j97ACPFibroblast growth factor receptor 2/0.450
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.449
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.448
4gmy0X5Tyrosine-protein kinase JAK2/0.447
2excJNKMitogen-activated protein kinase 102.7.11.240.446
2itqITQEpidermal growth factor receptor2.7.10.10.446
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.445
2vx07X7Ephrin type-B receptor 42.7.10.10.445
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.444
2pwlACPFibroblast growth factor receptor 2/0.444
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.444
2vww7X2Ephrin type-B receptor 42.7.10.10.443
2py3ACPFibroblast growth factor receptor 2/0.442
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.442
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.441
3efwAK8Aurora kinase A2.7.11.10.441
3oom507Activin receptor type-12.7.11.300.441
3vjoANPEpidermal growth factor receptor2.7.10.10.441
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.441
4jbpYPHAurora kinase A2.7.11.10.441
2itvANPEpidermal growth factor receptor2.7.10.10.440
2pzpACPFibroblast growth factor receptor 2/0.440
2v7a627Tyrosine-protein kinase ABL12.7.10.20.440
2yn8STUEphrin type-B receptor 42.7.10.10.440
4k33ACPFibroblast growth factor receptor 32.7.10.10.440
5e8ySTUTGF-beta receptor type-22.7.11.300.440