scPDB - Distribution of Cavity Similarity values of 4x5f entry / Site 1

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4x5f	FOL	Dihydrofolate reductase	1.5.1.3

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity
4x5f	FOL	Dihydrofolate reductase	1.5.1.3	1.000
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.564
4x5g	FOL	Dihydrofolate reductase	1.5.1.3	0.564
1rd7	FOL	Dihydrofolate reductase	1.5.1.3	0.540
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.538
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.527
1ra2	FOL	Dihydrofolate reductase	1.5.1.3	0.511
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.511
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.497
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.495
4x5j	FOL	Dihydrofolate reductase	1.5.1.3	0.494
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.492
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.488
1rx3	MTX	Dihydrofolate reductase	1.5.1.3	0.487
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.486
4dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.483
4ej1	FOL	Dihydrofolate reductase	1.5.1.3	0.482
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.481
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.477
5hi6	MTX	Dihydrofolate reductase	/	0.477
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.476
2w3v	TOP	Dihydrofolate reductase	/	0.475
4x5i	FOL	Dihydrofolate reductase	1.5.1.3	0.473
3ia4	MTX	Dihydrofolate reductase	/	0.472
4fhb	FOL	Dihydrofolate reductase	1.5.1.3	0.472
3qgt	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.469
1df7	MTX	Dihydrofolate reductase	1.5.1.3	0.468
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.468
1j3j	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.464
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.464
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.464
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.463
3qlx	QLR	Uncharacterized protein	/	0.461
3um6	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.461
3cse	N22	Uncharacterized protein	/	0.460
1drb	MTX	Dihydrofolate reductase	1.5.1.3	0.457
3eem	53V	Uncharacterized protein	/	0.457
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.456
3qlz	QLZ	Uncharacterized protein	/	0.455
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.450
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.450
2blc	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.448
3irn	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.448
4h98	14Q	Uncharacterized protein	/	0.447
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.447
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.445
2zza	FOL	Dihydrofolate reductase	/	0.444
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.444
3qg2	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.444
3sa1	6DR	Dihydrofolate reductase	/	0.444
1m78	CLZ	Dihydrofolate reductase	1.5.1.3	0.443
3eej	53R	Uncharacterized protein	/	0.443
1dg7	WRB	Dihydrofolate reductase	1.5.1.3	0.442
1ra3	MTX	Dihydrofolate reductase	1.5.1.3	0.442
3fre	TOP	Dihydrofolate reductase	1.5.1.3	0.442
1rb2	FOL	Dihydrofolate reductase	1.5.1.3	0.440