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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4nm5ADPGlycogen synthase kinase-3 beta2.7.11.26

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4nm5ADPGlycogen synthase kinase-3 beta2.7.11.261.000
4nm7ADPGlycogen synthase kinase-3 beta2.7.11.260.679
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.260.665
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.590
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.513
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.495
1u5rATPSerine/threonine-protein kinase TAO22.7.11.10.488
4ii5ADPCyclin-dependent kinase 22.7.11.220.488
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.485
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.483
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.477
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.476
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.475
4jrnANPRhoptry kinase family protein/0.474
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.473
3du8553Glycogen synthase kinase-3 beta2.7.11.260.473
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.471
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.468
4riyADPEpidermal growth factor receptor2.7.10.10.466
4qmlANPSerine/threonine-protein kinase 242.7.11.10.464
4y12AGSSerine/threonine-protein kinase PknG2.7.11.10.464
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.462
1qmzATPCyclin-dependent kinase 22.7.11.220.461
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.461
2bxnIDBSerum albumin/0.460
3okxSAMS-adenosyl-L-methionine-binding protein RPA0152/0.460
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.459
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.457
1hk3T44Serum albumin/0.455
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.455
4eooATPCyclin-dependent kinase 22.7.11.220.455
4s32ANPMitogen-activated protein kinase 12.7.11.240.455
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.454
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.453
2bxiAZQSerum albumin/0.452
4j711JXGlycogen synthase kinase-3 beta2.7.11.260.452
3g6wGTPUracil phosphoribosyltransferase2.4.2.90.451
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.451
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.450
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.449
3qc9ADPRhodopsin kinase/0.449
2x1eX1EAcyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 40 kDa form2.3.1.1640.448
3wowANPCasein kinase II subunit alpha2.7.11.10.448
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.448
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.446
3zrlZRLGlycogen synthase kinase-3 beta2.7.11.260.446
4k33ACPFibroblast growth factor receptor 32.7.10.10.446
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.445
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.445
4jia1K3Tyrosine-protein kinase JAK2/0.445
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.445
4i3zADPCyclin-dependent kinase 22.7.11.220.444
1gy3ATPCyclin-dependent kinase 22.7.11.220.443
4bbe3O4Tyrosine-protein kinase JAK2/0.443
4bgg844Activin receptor type-12.7.11.300.443
4s33ANPMitogen-activated protein kinase 12.7.11.240.443
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.442
4qms1N1Serine/threonine-protein kinase 242.7.11.10.442
2py3ACPFibroblast growth factor receptor 2/0.441
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.440
3vn9ANKDual specificity mitogen-activated protein kinase kinase 62.7.12.20.440
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.440