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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4la1FADThioredoxin glutathione reductase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4la1FADThioredoxin glutathione reductase/1.000
4dnaFADProbable glutathione reductase/0.588
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.573
1fecFADTrypanothione reductase1.8.1.120.572
1grhFADGlutathione reductase, mitochondrial1.8.1.70.570
2hqmFADGlutathione reductase1.8.1.70.565
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.559
1tytFADTrypanothione reductase1.8.1.120.554
2jk6FADTrypanothione reductase/0.550
4j56FADThioredoxin reductase 21.8.1.90.544
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.539
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.507
2wbaFADTrypanothione reductase1.8.1.120.504
1gxfFADTrypanothione reductase1.8.1.120.499
2v6oFADThioredoxin glutathione reductase/0.499
2x8hFADThioredoxin glutathione reductase/0.496
1bzlFADTrypanothione reductase1.8.1.120.475
4nevFADTrypanothione reductase/0.472
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.461
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.459
2eq9FADDihydrolipoyl dehydrogenase/0.453
1dncFADGlutathione reductase, mitochondrial1.8.1.70.450
3grsFADGlutathione reductase, mitochondrial1.8.1.70.440