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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4k41ATPActin, alpha skeletal muscle

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4k41ATPActin, alpha skeletal muscle/1.000
4pl8ATPActin, alpha skeletal muscle/0.591
3eksATPActin-5C/0.559
1qz5ATPActin, alpha skeletal muscle/0.558
1s22ATPActin, alpha skeletal muscle/0.557
1t44ATPActin, alpha skeletal muscle/0.551
4ci6ATPActin/0.546
4pkgATPActin, alpha skeletal muscle/0.545
3el2ATPActin-5C/0.544
1rgiATPActin, alpha skeletal muscle/0.533
4k43ADPActin, alpha skeletal muscle/0.528
2q36ATPActin, alpha skeletal muscle/0.527
3mn7ATPActin-5C/0.525
3tu5ATPActin, alpha skeletal muscle/0.519
3a5mATPMajor actin/0.518
1c0fATPMajor actin/0.516
1eqyATPActin, alpha skeletal muscle/0.514
2q97ATPActin, alpha skeletal muscle/0.508
4cbxATPActin-2/0.508
4jhdANPActin-5C/0.508
5ce3ATPActin/0.504
3dawATPActin, alpha skeletal muscle/0.503
3ffkATPActin, alpha skeletal muscle/0.502
1yxqATPActin, alpha skeletal muscle/0.498
2p9kATPActin-related protein 2/0.498
1dejATPMajor actin/0.488
1ijjATPActin, alpha skeletal muscle/0.479
2oanATPActin, cytoplasmic 1/0.477
3u9dATPActin, alpha skeletal muscle/0.470
3a5oATPMajor actin/0.451